College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang 310036, China.
J Neurosci. 2010 Jun 16;30(24):8245-50. doi: 10.1523/JNEUROSCI.1169-10.2010.
In the developing CNS, neurons and glia are sequentially produced from the ventricular neural progenitor cells. One fundamental question in developmental neurobiology is what signals or factors control the developmental switch from neurogenesis to gliogenesis. Here we report that microRNAs (miRNAs) play an essential role in this important developmental process. Inhibition of miRNA formation in Olig1(Cre)-mediated Dicer conditional knock-out mice disrupted both oligodendrogenesis and astrogliogenesis in the ventral neuroepithelial cells. By contrast, the early patterning and development of motor neurons were not affected in the mutant spinal cord tissue.
在中枢神经系统的发育过程中，神经元和神经胶质细胞是从脑室神经祖细胞中依次产生的。发育神经生物学的一个基本问题是，是什么信号或因素控制着从神经发生到神经胶质发生的发育转变。在这里，我们报告说 microRNAs（miRNAs）在这个重要的发育过程中起着至关重要的作用。在 Olig1(Cre)-介导的 Dicer 条件性敲除小鼠中抑制 miRNA 的形成，破坏了腹侧神经上皮细胞中的少突胶质细胞发生和星形胶质细胞发生。相比之下，突变脊髓组织中的运动神经元的早期模式形成和发育没有受到影响。
