Loseva M I, Shpagina L A, Sharapov V I, Sazonova O V, Grek O R
Gig Tr Prof Zabol. 1991(2):19-21.
Spectrographic studies of fat acids in erythrocytic membranes and lipid peroxidation (LPO) contributed to the identification of different phases in the formation of damage effects. Exposition to toxic complexes (mostly solvents) in the first year caused a predominant growth of the antioxidant systems' activity characteristic of the processes of adaptation. In case with the work duration from one to five years, the u saturated fat acid content growth was accompanied by both pro- and antioxidative processes, which was indicative of the compensatory nature of the revealed changes. The most vivid shifts in the LPO reactions and the fat acids' content in erythrocytic membranes were found in the occupational group of patients engaged in the profession for more than 5 years. Those included major changes in the spectrum of both saturated and unsaturated acids, LPO activation with concomitant depression of the antioxidative systems.
对红细胞膜中脂肪酸和脂质过氧化（LPO）的光谱研究有助于识别损伤效应形成的不同阶段。第一年接触有毒复合物（主要是溶剂）导致抗氧化系统活性显著增强，这是适应过程的特征。对于工作年限为1至5年的情况，不饱和脂肪酸含量的增长伴随着促氧化和抗氧化过程，这表明所揭示的变化具有补偿性质。在从事该职业超过5年的患者职业组中，发现红细胞膜中LPO反应和脂肪酸含量的变化最为明显。这些变化包括饱和脂肪酸和不饱和脂肪酸谱的重大变化、LPO激活以及抗氧化系统的相应抑制。
