[Indicators of lipid peroxidation and erythrocyte membrane permeability in patients with myasthenia gravis].

Twenty-five patients suffering from myasthenia with no thymectomy were examined for lipid peroxidation (LPO) and erythrocytic membrane permeability. A study was also made of spontaneous and induced LPO, the level of diene conjugates and permeability of the erythrocytic membranes in mixtures of isotonic urea and sodium chloride solutions of varying volumetric concentrations. LPO activation which was coupled with an increase of erythrocytic membrane permeability was revealed. The data obtained point to the impairment of membrane apparatus function in patients with myasthenia and allow recommending the use of the membrane-stabilizing therapy.