医学：SREBP 内含子使 HDL 微小 RNA 下调。
Medicine. HDL miR-ed down by SREBP introns.
机构信息
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
出版信息
Science. 2010 Jun 18;328(5985):1495-6. doi: 10.1126/science.1192409.
Abstract
Animal cells must maintain a membrane cholesterol-to-phospholipid ratio within tight limits for normal function. Elaborate mechanisms control the cellular input of cholesterol from endogenous synthesis or uptake from plasma lipoproteins. Much less is known about the factors that regulate the output of cholesterol from cells. On pages 1566 and 1570 of this issue, Najafi-Shoushtari et al. (1) and Rayner et al. (2) show that cholesterol output is controlled by the same genes that regulate cholesterol input, but in a reciprocal manner and through an unexpected mechanism.
摘要
动物细胞必须将膜胆固醇与磷脂的比例维持在严格的范围内，以维持正常功能。复杂的机制控制着胆固醇从内源性合成或从血浆脂蛋白摄取进入细胞。关于调节细胞内胆固醇输出的因素知之甚少。在本期的 1566 页和 1570 页上，Najafi-Shoushtari 等人(1)和 Rayner 等人(2)表明，胆固醇的输出受调节胆固醇摄取的相同基因控制，但以一种相反的方式，并通过一种意想不到的机制。
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本文引用的文献
1
MiR-33 contributes to the regulation of cholesterol homeostasis.
Science. 2010 Jun 18;328(5985):1570-3. doi: 10.1126/science.1189862. Epub 2010 May 13.
2
MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis.
Science. 2010 Jun 18;328(5985):1566-9. doi: 10.1126/science.1189123. Epub 2010 May 13.
3
Mouse models of the metabolic syndrome.
Dis Model Mech. 2010 Mar-Apr;3(3-4):156-66. doi: 10.1242/dmm.003467.
4
ABCA1: at the nexus of cholesterol, HDL and atherosclerosis.
Trends Biochem Sci. 2007 Apr;32(4):172-9. doi: 10.1016/j.tibs.2007.02.001. Epub 2007 Feb 26.
5
Fatty acid auxotrophy in Drosophila larvae lacking SREBP.
Cell Metab. 2006 Jun;3(6):439-48. doi: 10.1016/j.cmet.2006.04.011.
6
Why Syndrome X? From Harold Himsworth to the insulin resistance syndrome.
Cell Metab. 2005 Jan;1(1):9-14. doi: 10.1016/j.cmet.2004.12.001.
7
Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.
Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11245-50. doi: 10.1073/pnas.0404297101. Epub 2004 Jul 20.
8
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.
J Clin Invest. 2002 May;109(9):1125-31. doi: 10.1172/JCI15593.
9
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.
Genes Dev. 2000 Nov 15;14(22):2819-30. doi: 10.1101/gad.844900.
10
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.
Cell. 1997 May 2;89(3):331-40. doi: 10.1016/s0092-8674(00)80213-5.
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