Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Science. 2010 Jun 18;328(5985):1495-6. doi: 10.1126/science.1192409.
Animal cells must maintain a membrane cholesterol-to-phospholipid ratio within tight limits for normal function. Elaborate mechanisms control the cellular input of cholesterol from endogenous synthesis or uptake from plasma lipoproteins. Much less is known about the factors that regulate the output of cholesterol from cells. On pages 1566 and 1570 of this issue, Najafi-Shoushtari et al. (1) and Rayner et al. (2) show that cholesterol output is controlled by the same genes that regulate cholesterol input, but in a reciprocal manner and through an unexpected mechanism.
动物细胞必须将膜胆固醇与磷脂的比例维持在严格的范围内，以维持正常功能。复杂的机制控制着胆固醇从内源性合成或从血浆脂蛋白摄取进入细胞。关于调节细胞内胆固醇输出的因素知之甚少。在本期的 1566 页和 1570 页上，Najafi-Shoushtari 等人(1)和 Rayner 等人(2)表明，胆固醇的输出受调节胆固醇摄取的相同基因控制，但以一种相反的方式，并通过一种意想不到的机制。
