Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan.
FEBS J. 2021 Nov;288(22):6315-6330. doi: 10.1111/febs.15678. Epub 2021 Jan 7.
Recently, advances in genomic technology such as RNA sequencing and genome-wide profiling have enabled the identification of considerable numbers of non-coding RNAs (ncRNAs). MicroRNAs have been studied for decades, leading to the identification of those with disease-causing and/or protective effects in vascular disease. Although other ncRNAs such as long ncRNAs have not been fully described yet, recent studies have indicated their important functions in the development of vascular diseases. Here, we summarize the current understanding of the mechanisms and functions of ncRNAs, focusing on microRNAs, circular RNAs and long ncRNAs in vascular diseases.
最近，RNA 测序和全基因组分析等基因组技术的进步使得大量非编码 RNA（ncRNA）得以被鉴定。microRNAs 已经被研究了几十年，导致了那些在血管疾病中具有致病和/或保护作用的 microRNAs 的鉴定。尽管其他 ncRNAs，如长 ncRNAs，尚未被充分描述，但最近的研究表明它们在血管疾病的发展中具有重要作用。在这里，我们总结了 ncRNAs 的机制和功能的最新认识，重点是 microRNAs、环状 RNA 和长 ncRNAs 在血管疾病中的作用。
