Aringer M, Kuhn A
Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany.
Z Rheumatol. 2010 Jul;69(5):389-92. doi: 10.1007/s00393-010-0628-y.
It should be obvious today that systemic lupus erythematosus (SLE) patients are better treated in an interdisciplinary approach. Nonetheless, the question remains as to whether cutaneous lupus erythematosus (CLE) indeed constitutes a disease entity of its own rather than the only recognized manifestation of oligosymptomatic SLE. The ACR criteria, designed for classification rather than diagnosis, are of limited value in answering this question. However, the concept of specific autoantibodies and immune complexes as inducers of various organ manifestations and analogous ideas on other autoantibody-mediated problems within and outside SLE argue for CLE as an existing entity. This is relevant for understanding the underlying immunopathogenesis, while less important for the appropriate therapy.
如今显而易见的是，系统性红斑狼疮（SLE）患者采用多学科方法治疗效果更佳。尽管如此，皮肤型红斑狼疮（CLE）是否确实构成一种独立的疾病实体，而非仅为轻症SLE的唯一公认表现，这一问题依然存在。美国风湿病学会（ACR）标准是为分类而非诊断设计的，在回答这个问题时价值有限。然而，特定自身抗体和免疫复合物作为各种器官表现诱导物的概念，以及关于SLE内外其他自身抗体介导问题的类似观点，都支持CLE作为一种现存实体的观点。这对于理解潜在的免疫发病机制具有重要意义，而对于适当治疗的重要性则较低。
