Department of Zoology, University of British Columbia, Vancouver, BC, Canada.
FEBS Lett. 2010 Jul 16;584(14):3013-20. doi: 10.1016/j.febslet.2010.05.038. Epub 2010 May 24.
Nucleoporin 153 (Nup153), a component of the nuclear pore complex (NPC), has been implicated in the interaction of the NPC with the nuclear lamina. Here we show that depletion of Nup153 by RNAi results in alteration of the organization of the nuclear lamina and the nuclear lamin-binding protein Sun1. More striking, Nup153 depletion induces a dramatic cytoskeletal rearrangement that impairs cell migration in human breast carcinoma cells. Our results point to a very prominent role of Nup153 in connection to cell motility that could be exploited in order to develop novel anti-cancer therapy.
核孔蛋白 153（Nup153）是核孔复合物（NPC）的一个组成部分，已被牵连到 NPC 与核纤层的相互作用中。在这里，我们表明，通过 RNAi 耗尽 Nup153 会导致核纤层和核纤层结合蛋白 Sun1 的组织发生改变。更引人注目的是，Nup153 的耗竭会诱导细胞骨架的剧烈重排，从而损害人乳腺癌细胞的迁移。我们的研究结果表明，Nup153 在与细胞运动相关的过程中起着非常重要的作用，这一作用可能被用来开发新的抗癌疗法。
