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核孔蛋白Nup153是脑祖细胞基础核迁移过程中Kif1a的锚定蛋白。

The nucleoporin Nup153 is the anchor for Kif1a during basal nuclear migration in brain progenitor cells.

作者信息

Falnikar Aditi, Quintremil Sebastian, Zhao Hung-Jun, Cheng Haw-Yuan, Helmer Paige, Tsai Jin-Wu, Vallee Richard B

机构信息

Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.

Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.

出版信息

Cell Rep. 2024 Dec 24;43(12):115008. doi: 10.1016/j.celrep.2024.115008. Epub 2024 Dec 11.

DOI:10.1016/j.celrep.2024.115008
PMID:39666457
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11702353/
Abstract

Radial glial progenitors (RGPs) are highly elongated epithelial cells that give rise to most stem cells, neurons, and glia in the vertebrate cerebral cortex. During development, the RGP nuclei exhibit a striking pattern of cell-cycle-dependent oscillatory movements known as interkinetic nuclear migration (INM), which we previously found to be mediated during G1 by the kinesin Kif1a and during G2 by cytoplasmic dynein, recruited to the nuclear envelope by the nucleoporins RanBP2 and Nup133. We now identify Nup153 as a nucleoporin anchor for Kif1a, responsible for G1-specific basal nuclear migration, providing a complete model for the mechanisms underlying this basic but mysterious behavior, with broad implications for understanding brain development.

摘要

放射状胶质祖细胞（RGPs）是高度伸长的上皮细胞，可产生脊椎动物大脑皮层中的大多数干细胞、神经元和神经胶质细胞。在发育过程中，RGP细胞核呈现出一种显著的细胞周期依赖性振荡运动模式，称为核内运动（INM），我们之前发现，在G1期由驱动蛋白Kif1a介导，在G2期由细胞质动力蛋白介导，通过核孔蛋白RanBP2和Nup133募集到核膜。我们现在确定Nup153是Kif1a的核孔蛋白锚定物，负责G1期特异性的基底核迁移，为这种基本但神秘行为的潜在机制提供了一个完整模型，对理解大脑发育具有广泛意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/611b/11702353/d80bd19e0bc5/nihms-2044439-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/611b/11702353/55de14a9959a/nihms-2044439-f0002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/611b/11702353/d80bd19e0bc5/nihms-2044439-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/611b/11702353/55de14a9959a/nihms-2044439-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/611b/11702353/5db811c209da/nihms-2044439-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/611b/11702353/dfe72bdf7c98/nihms-2044439-f0004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/611b/11702353/90e2e379f791/nihms-2044439-f0006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/611b/11702353/d80bd19e0bc5/nihms-2044439-f0008.jpg

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本文引用的文献

1
Insight into the regulation of axonal transport from the study of KIF1A-associated neurological disorder.从 KIF1A 相关神经疾病研究看轴突运输的调控。
J Cell Sci. 2023 Mar 1;136(5). doi: 10.1242/jcs.260742. Epub 2023 Jan 19.
2
Architecture of the cytoplasmic face of the nuclear pore.核孔胞质面的结构。
Science. 2022 Jun 10;376(6598):eabm9129. doi: 10.1126/science.abm9129.
3
NUP153 promotes HCC cells proliferation via c-Myc-mediated downregulation of P15.NUP153 通过 c-Myc 介导下调 P15 促进 HCC 细胞增殖。
Dig Liver Dis. 2022 Dec;54(12):1706-1715. doi: 10.1016/j.dld.2022.02.008. Epub 2022 Mar 11.
4
Coil-to-α-helix transition at the Nup358-BicD2 interface activates BicD2 for dynein recruitment.核孔复合体蛋白 Nup358 与 BicD2 界面处的线圈到α-螺旋的转变激活 BicD2 以招募动力蛋白。
Elife. 2022 Mar 1;11:e74714. doi: 10.7554/eLife.74714.
5
Genotype and defects in microtubule-based motility correlate with clinical severity in -associated neurological disorder.基于微管的运动能力的基因型和缺陷与相关神经障碍的临床严重程度相关。
HGG Adv. 2021 Apr 8;2(2). doi: 10.1016/j.xhgg.2021.100026. Epub 2021 Jan 30.
6
Adapter Proteins for Opposing Motors Interact Simultaneously with Nuclear Pore Protein Nup358.衔接蛋白与核孔蛋白 Nup358 同时相互作用。
Biochemistry. 2019 Dec 17;58(50):5085-5097. doi: 10.1021/acs.biochem.9b00907. Epub 2019 Dec 6.
7
Going Too Far Is the Same as Falling Short: Kinesin-3 Family Members in Hereditary Spastic Paraplegia.过犹不及：遗传性痉挛性截瘫中的驱动蛋白-3家族成员
Front Cell Neurosci. 2019 Sep 26;13:419. doi: 10.3389/fncel.2019.00419. eCollection 2019.
8
Role of Coiled-Coil Registry Shifts in the Activation of Human Bicaudal D2 for Dynein Recruitment upon Cargo Binding.卷曲螺旋结构域移位在货物结合时人双尾D2激活动力蛋白募集过程中的作用
J Phys Chem Lett. 2019 Aug 1;10(15):4362-4367. doi: 10.1021/acs.jpclett.9b01865. Epub 2019 Jul 22.
9
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Cell Rep. 2018 Jul 17;24(3):685-700. doi: 10.1016/j.celrep.2018.06.071.
10
Rodent models in neuroscience research: is it a rat race?神经科学研究中的啮齿动物模型：这是一场激烈的竞争吗？
Dis Model Mech. 2016 Oct 1;9(10):1079-1087. doi: 10.1242/dmm.026120.