Markholst H, Eastman S, Wilson D, Andreasen B E, Lernmark A
Department of Medicine, University of Washington, Seattle 98195.
J Exp Med. 1991 Jul 1;174(1):297-300. doi: 10.1084/jem.174.1.297.
Diabetes-prone (DP) BB rats spontaneously develop insulin-dependent diabetes resembling type 1 diabetes mellitus in man. They also exhibit lifelong T cell deficiency. The segregation of both diabetes and lymphopenia was studied in crosses between this inbred line of rats and the related but nondiabetic and nonlymphopenic inbred diabetes-resistant (DR) BB rat line. Diabetes segregated as a single, autosomal recessive trait and was always accompanied by lymphopenia. Among the limited number of differences in the genomic DNA sequences of the two lines, DP and DR BB, one may account for the development of diabetes and lymphopenia in the DP BB rats. It may be possible to screen the genomic DNA for such differences to detect a marker for the phenotypes.
易患糖尿病（DP）的BB大鼠会自发发展出类似人类1型糖尿病的胰岛素依赖型糖尿病。它们还表现出终身性T细胞缺陷。在这种近交系大鼠与相关但非糖尿病且无淋巴细胞减少症的近交抗糖尿病（DR）BB大鼠品系之间的杂交后代中，对糖尿病和淋巴细胞减少症的遗传分离情况进行了研究。糖尿病作为单一的常染色体隐性性状进行遗传分离，并且总是伴有淋巴细胞减少症。在DP和DR BB这两个品系的基因组DNA序列中，存在数量有限的差异，其中一个差异可能是导致DP BB大鼠出现糖尿病和淋巴细胞减少症的原因。有可能对基因组DNA进行此类差异筛选，以检测出这些表型的标记物。
