黄连中新的弱抗痉挛原小檗碱生物碱。
A new and weakly antispasmodic protoberberine alkaloid from Rhizoma Coptidis.
机构信息
School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong.
出版信息
Phytother Res. 2010 Sep;24(9):1414-6. doi: 10.1002/ptr.3154.
DOI:10.1002/ptr.3154
PMID:20564546
Abstract
A new protoberberine alkaloid, 3-hydroxy-2-methoxy-9,10-methylenedioxy-8-oxo-protoberberine, along with three known compounds, was isolated from Rhizoma Coptidis. The new compound displayed weak antispasmodic activity against acetylcholine-induced contraction in isolated guinea-pig ileum with an IC50 of 83.7 microm.
摘要
从黄连根茎中分离得到一个新的原小檗碱生物碱，3-羟基-2-甲氧基-9,10-亚甲二氧基-8-氧代原小檗碱，以及三个已知化合物。该新化合物对乙酰胆碱诱导的离体豚鼠回肠收缩显示出较弱的抗痉挛活性，IC50 为 83.7 微米。
Zotero 插件