La Jolla Institute of Allergy and Immunology, La Jolla, CA 92037, USA.
Viral Immunol. 2010 Jun;23(3):259-84. doi: 10.1089/vim.2010.0006.
A meta-analysis was performed in order to inventory the immune epitope data related to viruses in the genus Flavivirus. Nearly 2000 epitopes were captured from over 130 individual Flavivirus-related references identified from PubMed and reported as of September 2009. This report includes all epitope structures and associated immune reactivity from the past and current literature, including: the epitope distribution among pathogens and related strains, the epitope distribution among different pathogen antigens, the number of epitopes defined in human and animal models of disease, the relationship between epitopes identified in different disease states following natural (or experimental) infection, and data from studies focused on candidate vaccines. We found that the majority of epitopes were defined for dengue virus (DENV) and West Nile virus (WNV). The prominence of DENV and WNV data in the epitope literature is likely a reflection of their overall worldwide impact on human disease, and the lack of vaccines. Conversely, the relatively smaller number of epitopes defined for the other viruses within the genus (yellow fever and Japanese encephalitis virus) most likely reflects the presence of established prophylaxis and/or their more modest impact on morbidity and mortality globally. Through this work we hope to provide useful data to those working in the area of Flavivirus research.
进行了一项荟萃分析，以盘点与黄病毒属病毒相关的免疫表位数据。从 PubMed 中检索到超过 130 篇与黄病毒相关的参考文献，并截至 2009 年 9 月报告，从中捕获了近 2000 个表位。本报告包括过去和当前文献中所有表位结构和相关免疫反应的信息，包括：病原体和相关株之间的表位分布、不同病原体抗原之间的表位分布、在人类和动物疾病模型中定义的表位数量、在自然（或实验）感染后不同疾病状态下鉴定的表位之间的关系，以及针对候选疫苗的研究数据。我们发现，大多数表位是针对登革热病毒（DENV）和西尼罗河病毒（WNV）定义的。在表位文献中，DENV 和 WNV 数据的突出地位很可能反映了它们对全球人类疾病的总体影响，以及缺乏疫苗。相反，在该属内其他病毒（黄热病和日本脑炎病毒）中定义的表位数量相对较少，这很可能反映了存在已确立的预防措施，或者它们对全球发病率和死亡率的影响较小。通过这项工作，我们希望为从事黄病毒研究的人员提供有用的数据。
