National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-6601, USA.
Viral Immunol. 2010 Jun;23(3):235-40. doi: 10.1089/vim.2009.0114.
On September 16, 2009, the National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. National Institutes of Health, convened a workshop to discuss current knowledge of T- and B-cell immune epitopes for members of the Flavivirus genus (family Flaviviridae), and how this information could be used to increase our basic understanding of host-pathogen interactions and/or advance the development of new or improved vaccines and diagnostics for these pathogens. B-cell and T-cell responses to flaviviruses are critical components of protective immunity against these pathogens. However, they have also been linked to disease pathogenesis. A detailed understanding of the biological significance of immune epitope information may provide clues regarding the mechanisms governing the induction of protective versus pathogenic adaptive immune responses.
2009 年 9 月 16 日，美国国立卫生研究院下属的过敏与传染病研究所（NIAID）召开了一次研讨会，讨论黄病毒属（黄病毒科）成员的 T 细胞和 B 细胞免疫表位的现有知识，以及如何利用这些信息增进我们对宿主-病原体相互作用的基本了解，和/或推动这些病原体的新型或改良疫苗和诊断方法的开发。针对黄病毒的 B 细胞和 T 细胞应答是针对这些病原体产生保护性免疫的关键组成部分。然而，它们也与疾病发病机制有关。对免疫表位信息的生物学意义的深入了解可能为阐明控制保护性与致病性适应性免疫应答诱导的机制提供线索。
