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普通人群中与寒冷相关的呼吸道症状。

Cold-related respiratory symptoms in the general population.

作者信息

Harju Terttu, Mäkinen Tiina, Näyhä Simo, Laatikainen Tiina, Jousilahti Pekka, Hassi Juhani

机构信息

Department of Internal Medicine, University of Oulu, Oulu, Finland.

出版信息

Clin Respir J. 2010 Jul;4(3):176-85. doi: 10.1111/j.1752-699X.2009.00172.x.

Abstract

INTRODUCTION

Cold-related respiratory symptoms are common among northern populations, especially among people suffering from respiratory diseases. However, the prevalence of such symptoms in the general population and the threshold temperatures at which the symptoms start to emerge are poorly known.

OBJECTIVES

The present study determined the prevalence and threshold temperatures of self-reported respiratory symptoms related to cold, separately for healthy people and those with respiratory disease.

MATERIALS AND METHODS

Six thousand five hundred ninety-one men and women aged 25 years-74 years from the national FINRISK study were queried about cold-related respiratory symptoms. The results were expressed as age-adjusted prevalence figures and coefficients from multivariate regressions.

RESULTS

Cold-related respiratory symptoms were more often reported by people with asthma (men 69%/women 78%) and by subjects with chronic bronchitis (65%/76%) than the healthy subjects (18%/21%). A binomial regression showed an increase of symptom prevalence by age and excesses of 4%, 50% and 21% units because of female sex, asthma and chronic bronchitis, respectively. The reported threshold temperature for cold-related symptoms was -14 degrees C for males and -15 degrees C for females, and it showed some increase by age (0 degrees C-5 degrees C), asthma (2 degrees C) and chronic bronchitis (3 degrees C). The threshold temperature for mucus production was exceptional as it decreased by age (2 degrees C-5 degrees C) and asthma (2 degrees C). The effects of smoking and education were marginal.

CONCLUSION

Cold-related respiratory symptoms are common in patients with chronic respiratory diseases, but they start to emerge at relatively low temperatures. In a cold climate, the cold-related symptoms may have an impact on the health-related quality of life.

摘要

引言

与寒冷相关的呼吸道症状在北方人群中很常见,尤其是在患有呼吸道疾病的人群中。然而,此类症状在普通人群中的患病率以及症状开始出现的阈值温度却鲜为人知。

目的

本研究分别确定了健康人群和患有呼吸道疾病人群中自我报告的与寒冷相关的呼吸道症状的患病率和阈值温度。

材料与方法

对来自全国FINRISK研究的6591名年龄在25岁至74岁之间的男性和女性询问了与寒冷相关的呼吸道症状。结果以年龄调整后的患病率数据和多变量回归系数表示。

结果

哮喘患者(男性69%/女性78%)和慢性支气管炎患者(65%/76%)比健康受试者(18%/21%)更常报告与寒冷相关的呼吸道症状。二项式回归显示,由于年龄、女性性别、哮喘和慢性支气管炎,症状患病率分别增加了4%、50%和21个百分点。报告的与寒冷相关症状的阈值温度男性为-14摄氏度,女性为-15摄氏度,并且随年龄(0摄氏度至5摄氏度)、哮喘(2摄氏度)和慢性支气管炎(3摄氏度)有所升高。黏液分泌的阈值温度特殊,随年龄(2摄氏度至5摄氏度)和哮喘(2摄氏度)降低。吸烟和教育程度的影响较小。

结论

与寒冷相关的呼吸道症状在慢性呼吸道疾病患者中很常见,但在相对较低的温度下就开始出现。在寒冷气候中,与寒冷相关的症状可能会对健康相关的生活质量产生影响。

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