Institut de Recherche pour le Développement, UMR 190, Marseille, France.
Virol J. 2010 Jun 17;7:132. doi: 10.1186/1743-422X-7-132.
To investigate West Nile virus (WNV) circulation in rural populations in Gabon, we undertook a large serological survey focusing on human rural populations, using two different ELISA assays. A sample was considered positive when it reacted in both tests. A total of 2320 villagers from 115 villages were interviewed and sampled. Surprisingly, the WNV-specific IgG prevalence was high overall (27.2%) and varied according to the ecosystem: 23.7% in forested regions, 21.8% in savanna, and 64.9% in the lakes region. The WNV-specific IgG prevalence rate was 30% in males and 24.6% in females, and increased with age. Although serological cross-reactions between flaviviruses are likely and may be frequent, these findings strongly suggest that WNV is widespread in Gabon. The difference in WNV prevalence among ecosystems suggests preferential circulation in the lakes region. The linear increase with age suggests continuous exposure of Gabonese populations to WNV. Further investigations are needed to determine the WNV cycle and transmission patterns in Gabon.
为了调查在加蓬农村人群中的西尼罗河病毒（WNV）传播情况，我们进行了一项大型血清学调查，重点关注人类农村人群，使用了两种不同的 ELISA 检测方法。当一个样本在两种检测中都呈阳性反应时，我们就认为它是阳性的。我们对来自 115 个村庄的 2320 名村民进行了访谈和抽样。令人惊讶的是，WNV 特异性 IgG 的总体流行率很高（27.2%），并且根据生态系统而有所不同：森林地区为 23.7%，稀树草原地区为 21.8%，湖泊地区为 64.9%。WNV 特异性 IgG 的流行率在男性中为 30%，在女性中为 24.6%，并随着年龄的增长而增加。尽管黄病毒之间可能存在血清学交叉反应，并且可能很频繁，但这些发现强烈表明 WNV 在加蓬广泛传播。不同生态系统之间 WNV 流行率的差异表明，WNV 在湖泊地区的循环更为普遍。与年龄的线性增加表明，加蓬人群不断受到 WNV 的暴露。需要进一步的调查来确定 WNV 在加蓬的循环和传播模式。
