Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706-1544, USA.
Antimicrob Agents Chemother. 2010 Sep;54(9):3988-90. doi: 10.1128/AAC.00067-10. Epub 2010 Jun 21.
Bacterial cytoskeletal proteins are an emerging set of targets for antibiotic development. This paper describes oligochlorophen analogs based on the monomer 4-chloro-2,6-dimethylphenol as antimicrobial agents against Bacillus anthracis. The most potent analogs have a MIC of 160 to 320 nM against B. anthracis and may target the cytoskeletal protein FtsZ. B. anthracis develops resistance to the oligochlorophens at a rate of 4.34 x 10(-10) per generation, which is approximately 10-fold lower than that of commercial antibiotics used to treat this human pathogen.
细菌细胞骨架蛋白是一组新兴的抗生素开发靶点。本文描述了基于单体 4-氯-2,6-二甲基苯酚的寡氯苯类似物，作为抗炭疽芽孢杆菌的抗菌剂。最有效的类似物对炭疽芽孢杆菌的 MIC 为 160 至 320 nM，可能针对细胞骨架蛋白 FtsZ。炭疽芽孢杆菌对寡氯苯的耐药性产生速度为每代 4.34 x 10(-10)，比用于治疗这种人类病原体的商业抗生素低约 10 倍。
