Beemon K L, Faras A J, Hasse A T, Duesberg P H, Maisel J E
J Virol. 1976 Feb;17(2):525-37. doi: 10.1128/JVI.17.2.525-537.1976.
The genetic complexities of several ribodeoxyviruses were measured by quantitative analysis of unique RNase T1-resistant oligonucleotides from 60-70S viral RNAs. Moloney murine leukemia virus was found to have an RNA complexity of 3.5 x 10(6) daltons, whereas Moloney murine sarcoma virus had a significantly smaller genome size of 2.3 x 10(6). Reticuleondotheliosis and visna virus RNAs had complexities of 3.9 x 10(6), respectively. Analysis of RNase A-resistant oligonucleotides of Rous sarcoma virus RNA gave a complexity of 3.6 x 10(6), similar to that previously obtained with RNase T1-resistant oligonucleotides. Since each of these viruses was found to have a unique sequence genomic complexity near the molecular weight of a single 30-40S viral RNA subunit, it was concluded that ribodeoxyvirus genomes are at least largely polyploid.
通过对60 - 70S病毒RNA中独特的抗核糖核酸酶T1寡核苷酸进行定量分析，测定了几种核糖脱氧病毒的遗传复杂性。发现莫洛尼氏鼠白血病病毒的RNA复杂性为3.5×10⁶道尔顿，而莫洛尼氏鼠肉瘤病毒的基因组大小明显较小，为2.3×10⁶。网状内皮增生症病毒和维斯纳病毒的RNA复杂性分别为3.9×10⁶。对劳氏肉瘤病毒RNA的抗核糖核酸酶A寡核苷酸分析得出的复杂性为3.6×10⁶，与先前用抗核糖核酸酶T1寡核苷酸得到的结果相似。由于发现这些病毒中的每一种在单个30 - 40S病毒RNA亚基的分子量附近都具有独特序列的基因组复杂性，因此得出结论，核糖脱氧病毒基因组至少在很大程度上是多倍体的。
