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[DMEK:Descemet 膜内皮角膜移植术]

[DMEK: Descemet membrane endothelial keratoplasty].

作者信息

Cursiefen C, Kruse F E

机构信息

Augenklinik mit Poliklinik, Friedrich-Alexander-Universität Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen.

出版信息

Ophthalmologe. 2010 Apr;107(4):370-6. doi: 10.1007/s00347-010-2155-2.

Abstract

BACKGROUND

Penetrating keratoplasty is at present the gold standard for surgical treatment of corneal endothelial pathologies but tremendous progress has been made in recent years in improving the technology of (posterior) lamellar keratoplasty techniques, such as Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping automated endothelial keratoplasty (DSAEK).

METHODS

A review of the literature was carried out using PUBMED and own clinical and experimental data.

RESULTS

Isolated transplantation of Descemet's membrane with endothelial cells after stripping the host Descemet's membrane is a new surgical technique for Fuchs endothelial dystrophy and pseudophakic bullous keratopathy. Visual rehabilitation seems to be faster and better with DMEK compared to penetrating keratoplasty.

CONCLUSION

Posterior lamellar keratoplasty techniques such as DMEK will replace penetrating keratoplasty as the gold standard for treatment of a large segment of corneal endothelial pathologies.

摘要

背景

穿透性角膜移植术目前是角膜内皮病变手术治疗的金标准,但近年来在改进(后)板层角膜移植技术方面取得了巨大进展,如Descemet膜内皮角膜移植术(DMEK)和Descemet膜剥除自动内皮角膜移植术(DSAEK)。

方法

使用PUBMED以及自身的临床和实验数据进行文献综述。

结果

在剥除宿主Descemet膜后,将Descemet膜与内皮细胞进行单独移植,是治疗Fuchs内皮营养不良和人工晶状体眼大泡性角膜病变的一种新手术技术。与穿透性角膜移植术相比,DMEK的视力恢复似乎更快、更好。

结论

诸如DMEK等后板层角膜移植技术将取代穿透性角膜移植术,成为治疗大部分角膜内皮病变的金标准。

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