School of Pharmacy and Pharmaceutical Sciences, Department of NanoEngineering, University of California at San Diego, La Jolla, California 92093, USA.
J Am Chem Soc. 2010 Jul 21;132(28):9540-2. doi: 10.1021/ja102595j.
A new light-sensitive polymer containing multiple light-sensitive triggering groups along the backbone and incorporating a quinone-methide self-immolative moiety was developed and formulated into nanoparticles encapsulating a model pharmaceutical Nile Red. Triggered burst release of the payload upon irradiation and subsequent degradation of the nanoparticles were observed. This system is designed to be versatile where the triggering group can be sensitive to a number of wavelengths.
一种新型的光敏感聚合物，在主链上含有多个光敏感触发基团，并结合了醌-亚甲醚自毁部分，被开发并制成纳米颗粒，包封了模型药物尼罗红。在照射后观察到了有效载荷的触发式爆发释放，以及随后纳米颗粒的降解。该系统旨在具有多功能性，其中触发基团可以对多种波长敏感。
