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Q 热作为不明原因发热和血小板增多症的病因:巴西首次发现柯克斯体的分子证据。

Q fever as a cause of fever of unknown origin and thrombocytosis: first molecular evidence of Coxiella burnetii in Brazil.

机构信息

Laboratory of Hantaviroses and Rickettsioses, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.

出版信息

Vector Borne Zoonotic Dis. 2011 Jan;11(1):85-7. doi: 10.1089/vbz.2009.0261. Epub 2010 Jun 23.

DOI:10.1089/vbz.2009.0261
PMID:20569012
Abstract

We report a case of Q fever in a man who presented with fever of 40 days duration associated with thrombocytosis. Serological and molecular analysis (polymerase chain reaction) confirmed infection with Coxiella burnetii. A field study was conducted by collecting blood samples from the patient's family and from the animals in the patient's house. The patient's wife and 2 of 13 dogs showed seroreactivity. Our data indicate that C. burnetii may be an underrecognized cause of fever in Brazil and emphasize the need for clinicians to consider Q fever in patients with a febrile illness, particularly those with a history of animal contact.

摘要

我们报告了一例 Q 热病例,患者发热 40 天,伴有血小板增多。血清学和分子分析(聚合酶链反应)证实感染了贝氏柯克斯体。通过收集患者家庭的血液样本和患者家中的动物的血液样本进行了现场研究。患者的妻子和 13 只狗中的 2 只显示出血清反应性。我们的数据表明,贝氏柯克斯体可能是巴西被低估的发热原因,并强调临床医生需要考虑 Q 热在发热患者中的可能性,特别是那些有动物接触史的患者。

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