Finally, a macaque model for cell-associated SIV/HIV vaginal transmission.
作者信息
Anderson Deborah J
出版信息
J Infect Dis. 2010 Aug 15;202(3):333-6. doi: 10.1086/653620.
Abstract
摘要
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Finally, a macaque model for cell-associated SIV/HIV vaginal transmission.最后，一种用于细胞相关的猴免疫缺陷病毒/人类免疫缺陷病毒阴道传播的猕猴模型。
J Infect Dis. 2010 Aug 15;202(3):333-6. doi: 10.1086/653620.
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Infection of macaques after vaginal exposure to cell-associated simian immunodeficiency virus.恒河猴经阴道接触细胞相关猴免疫缺陷病毒后的感染。
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SIV/DeltaB670 transmission across oral, colonic, and vaginal mucosae in the macaque.猕猴中SIV/DeltaB670经口腔、结肠和阴道黏膜的传播
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Targeted lymph-node immunization with whole inactivated simian immunodeficiency virus (SIV) or envelope and core subunit antigen vaccines does not reliably protect rhesus macaques from vaginal challenge with SIVmac251.用全灭活猴免疫缺陷病毒（SIV）或包膜及核心亚单位抗原疫苗进行靶向淋巴结免疫，不能可靠地保护恒河猴免受SIVmac251的阴道攻击。
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Occult systemic infection and persistent simian immunodeficiency virus (SIV)-specific CD4(+)-T-cell proliferative responses in rhesus macaques that were transiently viremic after intravaginal inoculation of SIV.恒河猴经阴道接种猴免疫缺陷病毒（SIV）后短暂病毒血症期间的隐匿性全身感染及持续性SIV特异性CD4(+) T细胞增殖反应
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Animal model of mucosally transmitted human immunodeficiency virus type 1 disease: intravaginal and oral deposition of simian/human immunodeficiency virus in macaques results in systemic infection, elimination of CD4+ T cells, and AIDS.黏膜传播的人类免疫缺陷病毒1型疾病的动物模型：将猿猴/人类免疫缺陷病毒经阴道和口腔接种于猕猴可导致全身感染、CD4+ T细胞耗竭及艾滋病。
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本文引用的文献
1
Infection of macaques after vaginal exposure to cell-associated simian immunodeficiency virus.恒河猴经阴道接触细胞相关猴免疫缺陷病毒后的感染。
J Infect Dis. 2010 Aug 15;202(3):337-44. doi: 10.1086/653619.
2
Targeting Trojan Horse leukocytes for HIV prevention.靶向特洛伊木马白细胞以预防艾滋病病毒
AIDS. 2010 Jan 16;24(2):163-87. doi: 10.1097/QAD.0b013e32833424c8.
3
Monkeying around with HIV vaccines: using rhesus macaques to define 'gatekeepers' for clinical trials.摆弄HIV疫苗：利用恒河猴为临床试验确定“把关因素”
Nat Rev Immunol. 2009 Oct;9(10):717-28. doi: 10.1038/nri2636.
4
Roadblocks in HIV research: five questions.艾滋病病毒研究中的障碍：五个问题
Nat Med. 2009 Aug;15(8):855-9. doi: 10.1038/nm0809-855.
5
Genital ulcers facilitate rapid viral entry and dissemination following intravaginal inoculation with cell-associated simian immunodeficiency virus SIVmac239.生殖器溃疡会促使在经阴道接种细胞相关的猿猴免疫缺陷病毒SIVmac239后病毒快速进入并扩散。
J Virol. 2008 Apr;82(8):4154-8. doi: 10.1128/JVI.01947-07. Epub 2008 Feb 13.
6
A dual chamber model of female cervical mucosa for the study of HIV transmission and for the evaluation of candidate HIV microbicides.用于研究HIV传播及评估候选HIV杀微生物剂的女性宫颈黏膜双腔模型。
Antiviral Res. 2007 May;74(2):111-24. doi: 10.1016/j.antiviral.2006.10.010. Epub 2006 Nov 7.
7
Repeated intravaginal inoculation with cell-associated simian immunodeficiency virus results in persistent infection of nonhuman primates.用细胞相关的猿猴免疫缺陷病毒反复进行阴道内接种会导致非人灵长类动物持续感染。
J Infect Dis. 2006 Oct 1;194(7):912-6. doi: 10.1086/507308. Epub 2006 Aug 29.
8
Lactobacilli-expressed single-chain variable fragment (scFv) specific for intercellular adhesion molecule 1 (ICAM-1) blocks cell-associated HIV-1 transmission across a cervical epithelial monolayer.对细胞间黏附分子1（ICAM-1）具有特异性的乳酸杆菌表达的单链可变片段（scFv）可阻断细胞相关的HIV-1跨宫颈上皮单层的传播。
J Immunol. 2006 May 1;176(9):5627-36. doi: 10.4049/jimmunol.176.9.5627.
9
Effect of heterosexual intercourse on mucosal alloimmunisation and resistance to HIV-1 infection.异性性交对黏膜同种免疫及HIV-1感染抵抗力的影响。
Lancet. 2004 Feb 14;363(9408):518-24. doi: 10.1016/S0140-6736(04)15538-4.
10
Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent.局部应用的膜修饰剂可阻断小鼠体内细胞相关HIV-1的阴道传播。
J Clin Invest. 2002 Jan;109(2):205-11. doi: 10.1172/JCI13236.
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