Vázquez-Martínez Osvaldo Tomás, Martínez-Rodríguez Herminia G, Velásquez-Arenas Leobardo, Baños-González Dolores, Ortíz-López Rocío, Padilla-Rivas Gerardo, Welsh Oliverio, Ocampo-Candiani Jorge
Dermatology Service, Dr. Jose E. Gonzalez University Hospital and Medical School, Autonomous University of Nuevo León, Monterrey, Nuevo León, México.
J Drugs Dermatol. 2011 Sep;10(9):1032-6.
Dermabrasion is a surgical procedure that has been used for repigmentation; however, autologous transplantation of uncultured melanocytes in a suspension combined with the use of adjunct treatment provides better results.
To evaluate the clinical effectiveness of dermoabrasion (DA) and melanocyte-keratinocyte cell suspension transplantation (DA+MKT) vs. dermabrasion with no adjunct treatment.
We selected 11 patients (six women and five men) with stable vitiligo. From these, two achromic maculae of similar size were selected. One macule was treated with DA+MKT and the other with DA only. The main parameter of treatment efficacy was the percentage of repigmentation in the area treated, three and 12 months after implantation.
In seven of the 11 patients, slightly better pigmentation occurred with DA+MKT. Two of these patients had a repigmentation greater than 50 percent and in two other patients, the result was similar for both techniques, although slightly better with MKT. Two more patients showed less than 20 percent repigmentation, but only in the area treated with DA+MKT. One patient showed pigmentation initially after DA+MKT only, and subsequent depigmentation.
DA+MKT produced slightly better repigmentation than DA only when given without adjunct treatment in a 12-month follow-up period.
磨皮术是一种用于色素沉着再形成的外科手术；然而，未培养的黑素细胞悬浮液自体移植联合辅助治疗可取得更好的效果。
评估磨皮术（DA）和黑素细胞 - 角质形成细胞悬浮液移植术（DA + MKT）与未进行辅助治疗的磨皮术相比的临床疗效。
我们选取了11例白癜风病情稳定的患者（6名女性和5名男性）。从这些患者中，选择两个大小相似的白斑。一个白斑采用DA + MKT治疗，另一个仅采用DA治疗。治疗效果的主要参数是植入后3个月和12个月时治疗区域的色素沉着恢复百分比。
11例患者中有7例采用DA + MKT治疗后色素沉着情况略好。其中2例患者色素沉着恢复超过50%，另外2例患者两种技术的效果相似，不过MKT治疗效果略好。另有2例患者色素沉着恢复低于20%，但仅在采用DA + MKT治疗的区域出现这种情况。1例患者仅在采用DA + MKT治疗后最初出现色素沉着，随后色素脱失。
在12个月的随访期内，与未进行辅助治疗的磨皮术相比，DA + MKT产生的色素沉着恢复效果略好。
