Tijsse-Klasen Ellen, Fonville Manoj, van Overbeek Leo, Reimerink Johan Hj, Sprong Hein
Laboratory for Zoonoses and Environmental Microbiology, National Institute for Public Health and Environment (RIVM), Antonie van Leeuwenhoeklaan 9, P,O, Box 1, Bilthoven, the Netherlands.
Parasit Vectors. 2010 Jun 22;3:54. doi: 10.1186/1756-3305-3-54.
Several pathogenic Rickettsia species can be transmitted via Ixodes ricinus ticks to humans and animals. Surveys of I. ricinus for the presence of Rickettsiae using part of its 16S rRNA gene yield a plethora of new and different Rickettsia sequences. Interpreting these data is sometimes difficult and presenting these findings as new or potentially pathogenic Rickettsiae should be done with caution: a recent report suggested presence of a known human pathogen, R. australis, in questing I. ricinus ticks in Europe. A refined analysis of these results revealed that R. helvetica was most likely to be misinterpreted as R. australis. Evidence in the literature is accumulating that rickettsial DNA sequences found in tick lysates can also be derived from other sources than viable, pathogenic Rickettsiae. For example, from endosymbionts, environmental contamination or even horizontal gene transfer.
几种致病性立克次体物种可通过蓖麻硬蜱传播给人类和动物。利用蓖麻硬蜱16S rRNA基因的一部分对其进行立克次体检测，得到了大量新的和不同的立克次体序列。解读这些数据有时很困难，将这些发现作为新的或潜在致病性立克次体呈现时应谨慎：最近一份报告表明，在欧洲采集的蓖麻硬蜱中存在已知的人类病原体澳大利亚立克次体。对这些结果的精细分析表明，瑞士立克次体最有可能被误判为澳大利亚立克次体。文献中的证据越来越多，表明在蜱裂解物中发现的立克次体DNA序列也可能来源于除活的致病性立克次体以外的其他来源。例如，来自内共生体、环境污染甚至水平基因转移。
