Biology of Vector-Borne Viruses Section, Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States.
Front Cell Infect Microbiol. 2020 Apr 8;10:142. doi: 10.3389/fcimb.2020.00142. eCollection 2020.
The deer tick transmits a variety of disease agents in the United States, spreading the bacteria that causes Lyme borreliosis, the protozoan agent of babesiosis, and viruses such as Powassan. However, a variety of other organisms have also evolved symbiotic relationships with this tick species, and it seems likely that some of these microbes have simultaneously coevolved mechanisms to impact each other and their tick host. The number of organisms identified as symbionts has increased seemingly exponentially with the advent of PCR and next generation sequencing technologies, but convincing arguments have proposed that some of these are of environmental origin, unadapted to surviving the physiological conditions of the tick or that they are artifacts of ultrasensitive detection methods. In this review, we examine the diversity of the known microbes occurring within the microbiome, the evidence for interactions between microbes, and discuss whether some organisms reported to be symbionts of are experimental artifacts.
鹿蜱在美国传播多种病原体，传播莱姆病螺旋体、巴贝斯虫原生动物剂和波瓦桑等病毒。然而，许多其他生物也与这种蜱建立了共生关系，而且似乎这些微生物中的一些已经同时进化出了相互影响及其蜱宿主的机制。随着 PCR 和下一代测序技术的出现，被确定为共生体的生物数量呈指数级增长，但有令人信服的观点认为，其中一些是环境来源的，不适应在蜱或超敏检测方法的生理条件下生存，它们是技术artifact。在这篇综述中，我们研究了微生物组中已知微生物的多样性、微生物之间相互作用的证据，并讨论了一些被报道为的共生体的生物是否是实验artifact。
