Women's Reproductive Health Key Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Int J Gynaecol Obstet. 2010 Sep;110(3):217-22. doi: 10.1016/j.ijgo.2010.03.040. Epub 2010 Jun 8.
To study short-term type-specific human papillomavirus (HPV) persistence and associated predictors in an asymptomatic general female population in Zhejiang, China.
Persistence was evaluated in women who were HPV positive at enrollment and who returned within 6-14 months. Liquid-based cytology screening was encouraged for returning women.
Persistence was evaluated in 548 women. Overall persistence was 49.1%, and established high-risk HPV persistence was 54.5%. The types associated with the highest level of persistence were HPV-52, HPV-58, HPV-56, and HPV-16-most of which belong to alpha9 species. In total, 252 women refused cytology screening. No differences were found regarding HPV persistence and other variables among women who returned for follow-up, women who accepted cytology screening, and women who refused cytology screening. Among women aged 35 years or older, there were no differences between those with normal cytology and those with abnormal cytology in the short-term persistence of HPV types, except for HPV-58 (P<0.01) and HPV-81 (P=0.04). Established high-risk HPV persistence increased with age, low income, and early sexual experience.
The data support close surveillance of older women with established high-risk HPV infections, and conservative management of women with non-alpha9 HPV and no risk factors.
研究中国浙江无症状一般女性人群中短期特定型别人乳头瘤病毒（HPV）持续性及其相关预测因素。
对在入组时 HPV 阳性且在 6-14 个月内返回的女性进行持续性评估。鼓励返回的女性进行液基细胞学筛查。
共评估了 548 名女性。总体持续性为 49.1%，已确定的高危型 HPV 持续性为 54.5%。与最高持续性相关的类型是 HPV-52、HPV-58、HPV-56 和 HPV-16-其中大多数属于 alpha9 种。总共有 252 名女性拒绝细胞学筛查。在返回随访的女性、接受细胞学筛查的女性和拒绝细胞学筛查的女性中，HPV 持续性和其他变量之间没有差异。在 35 岁及以上的女性中，除 HPV-58（P<0.01）和 HPV-81（P=0.04）外，细胞学正常和细胞学异常的女性 HPV 类型短期持续性无差异。已确定的高危型 HPV 持续性随年龄、低收入和早期性经历而增加。
数据支持对已确定高危型 HPV 感染的老年女性进行密切监测，并对无 alpha9 HPV 和无危险因素的女性进行保守管理。
