Tao Pingping, Zheng Weiping, Meng Xiaohua, Chen Junxia, Sun Aijing, Shou Qinghe, Wang Yungen, Yang Binlie
Department of Obstetrics and Gynecology, Shanghai Pudong New Area People's Hospital, Shanghai 201299, P.R. China.
Department of Gynaecology, Shaoxing People's Hospital, Shaoxing, Zhejiang 312000, P.R. China.
Mol Clin Oncol. 2017 Dec;7(6):957-964. doi: 10.3892/mco.2017.1454. Epub 2017 Oct 17.
The aim of the present study was to investigate the effect of the traditional Chinese medicine paiteling on the outcome of high-risk human papillomavirus (HR-HPV) infection of the cervix. A total of 321 patients were enrolled in this study and HPV subtypes were determined by the Hybribio HPV genotyping system. The patients were divided into the loop electrosurgical excision procedure (LEEP; n=82) and non-LEEP (n=239) groups, according to the cervical intraepithelial neoplasia classification. These two groups were further subdivided into the drug (paiteling) and control subgroups. Thin-prep cytology and HR-HPV tests were performed every 3 months for 1 year. In the non-LEEP group, the negative conversion rate of HR-HPV and the regression rate of the cervical lesions in drug subgroup were significantly higher compared with those in the control subgroup. In the LEEP group, the seroconversion rate of the drug subgroup, but not the regression rate of the lesions, was significantly higher compared with that in the control subgroup. The seroconversion rate of HPV16-infected patients at 12 months was 85.7%, whereas it reached 100% in all other HPV subtypes. Therefore, paiteling may accelerate the clearance of HPV infection and the regression of cervical lesions.
本研究旨在探讨中药派特灵对宫颈高危型人乳头瘤病毒（HR-HPV）感染结局的影响。本研究共纳入321例患者，采用凯普HPV基因分型系统确定HPV亚型。根据宫颈上皮内瘤变分类，将患者分为环形电切术（LEEP；n = 82）组和非LEEP（n = 239）组。这两组又进一步分为药物（派特灵）亚组和对照组。在1年的时间里，每3个月进行一次薄层液基细胞学检查和HR-HPV检测。在非LEEP组中，药物亚组的HR-HPV转阴率和宫颈病变消退率显著高于对照组。在LEEP组中，药物亚组的血清转化率显著高于对照组，但病变消退率无显著差异。HPV16感染患者12个月时的血清转化率为85.7%，而其他所有HPV亚型的血清转化率均达到100%。因此，派特灵可能会加速HPV感染的清除和宫颈病变的消退。
