Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 906 S Goodwin Ave, Urbana, IL 61801, United States.
Neurosci Lett. 2010 Aug 2;479(3):307-11. doi: 10.1016/j.neulet.2010.05.086. Epub 2010 Jun 4.
This study compared the effect of acute bouts of unloaded arm versus leg cycling exercise on spasticity of the lower legs in persons with multiple sclerosis (MS) and then examined post-activation depression (PAD) as a possible mechanism for the anti-spastic effects of acute exercise. Participants (N=10) had relapsing-remitting MS, slight to moderate spasticity of the soleus muscle, and were independently ambulatory. Spasticity was measured in the soleus muscle using the H-reflex and modified Ashworth scale (MAS). PAD was measured in the soleus muscle based on a simple, standardized protocol for modifying the parameters for evoking the H-reflex. In three separate sessions participants undertook 20min of either unloaded arm cycling exercise, unloaded leg cycling exercise, or control (quiet sitting) conditions in a random order, and data were collected before and after all three conditions. The H-reflex and MAS were significantly decreased after both unloaded arm and leg cycling exercise and significantly increased after quiet sitting. There was no change over time in PAD among the conditions. The reduction in the H-reflex was approximately 50% larger after leg than arm cycling exercise, whereas the reduction in MAS scores was approximately 20% larger after leg than arm cycling exercise. Such findings provide support for anti-spastic potential of both arm and leg cycling exercise on spasticity of the legs, but indicate that the effect is larger for the musculature that is activated during cycling and not explained by PAD.
这项研究比较了急性无负荷手臂和腿部循环运动对多发性硬化症（MS）患者小腿痉挛的影响，然后检查了运动后抑制（PAD）作为急性运动抗痉挛作用的可能机制。参与者（N=10）患有复发缓解型多发性硬化症，比目鱼肌有轻度至中度痉挛，并且能够独立行走。使用 H 反射和改良 Ashworth 量表（MAS）测量比目鱼肌的痉挛程度。根据一种简单的标准化方案，在三个单独的会话中，根据改变诱发 H 反射的参数，在比目鱼肌中测量 PAD。参与者以随机顺序分别进行 20 分钟的无负荷手臂循环运动、无负荷腿部循环运动或对照（安静坐姿）条件，在所有三种条件之前和之后收集数据。无负荷手臂和腿部循环运动后 H 反射和 MAS 均显著降低，安静坐姿后显著升高。在条件之间，PAD 没有随时间变化。腿部循环运动后 H 反射的降低幅度比手臂循环运动大约大 50%，而 MAS 评分的降低幅度比手臂循环运动大约大 20%。这些发现为手臂和腿部循环运动对腿部痉挛的抗痉挛潜力提供了支持，但表明对于在循环运动中激活的肌肉，其效果更大，而不是由 PAD 解释。
