Orthopedic Department, Ludwig-Maximilians-University, Campus Großhadern, Marchioninistraße 15, 81377 Munich, Germany.
Acta Biomater. 2010 Nov;6(11):4296-304. doi: 10.1016/j.actbio.2010.06.002. Epub 2010 Jun 8.
Poly(ether ether ketone) (PEEK) and its composites are recognized as alternative bearing materials for use in arthroplasty because of their mechanical properties. The objective of this project was to evaluate the biological response of two different kinds of carbon fiber-reinforced (CFR) PEEK compared with ultra-high molecular weight polyethylene (UHMWPE) in vivo as a standard bearing material. Wear particles of the particulate biomaterials were injected into the left knee joint of female BALB/c mice. Assessment of the synovial microcirculation using intravital fluorescence microscopy as well as histological evaluation of the synovial layer were performed 7 days after particle injection. Enhanced leukocyte-endothelial cell interactions and an increase in functional capillary density as well as histological investigations revealed that all tested biomaterials caused significantly (P < 0.05) increased inflammatory reactions compared with control animals (injected with sterile phosphate-buffered saline), without any difference between the tested biomaterials (P > 0.05). These data suggest that wear debris of CFR-PEEK is comparable with UHMWPE in its biological activity. Therefore, CFR-PEEK represents an alternative bearing material because of its superior mechanical and chemical behavior without any increased biological activity of the wear particles, compared with a standard bearing material.
聚醚醚酮（PEEK）及其复合材料因其机械性能而被认为是关节置换中替代轴承材料的选择。本项目的目的是评估两种不同碳纤维增强（CFR）PEEK 与超高分子量聚乙烯（UHMWPE）作为标准轴承材料在体内的生物反应。将颗粒状生物材料的磨损颗粒注入雌性 BALB/c 小鼠的左膝关节。在颗粒注射后 7 天，使用活体荧光显微镜评估滑膜微循环，并对滑膜层进行组织学评估。增强的白细胞-内皮细胞相互作用和功能毛细血管密度的增加以及组织学研究表明，与对照动物（注射无菌磷酸盐缓冲盐水）相比，所有测试的生物材料都引起了明显的（P < 0.05）炎症反应，而测试的生物材料之间没有差异（P > 0.05）。这些数据表明，CFR-PEEK 的磨损碎片在其生物活性方面与 UHMWPE 相当。因此，与标准轴承材料相比，由于其优越的机械和化学性能，而磨损颗粒的生物活性没有增加，CFR-PEEK 代表了一种替代轴承材料。
