Khanna Ashutosh, Jain Pushpdant, Paul C P
School of Mechanical Engineering, VIT Bhopal University, Bhopal-Indore Highway, Kothri Kalan, Dist. Sehore, Madhya Pradesh, India, 466114.
Laser Additive Manufacturing Laboratory, Laser Technology Division, Raja Ramanna Centre for Advanced Technology, Indore, Madhya Pradesh, India, 452013.
Med Biol Eng Comput. 2025 May 10. doi: 10.1007/s11517-025-03371-5.
In lumbar total disc replacement, artificial disc implants are utilized to cure degenerative disc disease and restore natural motion. Human intervertebral discs (IVD) are part of the spine and contribute to delivering six degrees of freedom, elastic deformation, and shock absorption and act differently under different load conditions. Despite advancements in spinal fixation systems and IVD replacement techniques, achieving long-term segmental stability while preserving physiological motion remains a significant challenge. To overcome this issue, the proposed work aims to identify the biomechanics of artificial IVD implants through rigorous analysis. The ultimate goal is to provide the information to explore the design and develop novel implants that seamlessly integrate with the spine, restoring natural spine function and providing long-term, sustainable load-bearing properties, mimicking the resilience and longevity of the natural IVD. To address all these issues, a comprehensive review of the literature was conducted, organizing findings based on body structure, associated diseases, biomechanics, and various IVD development models. The present endeavour involves a critical analysis with the aim of facilitating the input to the design and development of novel IVD implants in the future.
在腰椎全椎间盘置换中，人工椎间盘植入物用于治疗椎间盘退变疾病并恢复自然运动。人类椎间盘（IVD）是脊柱的一部分，有助于实现六个自由度、弹性变形和减震功能，并且在不同负荷条件下表现不同。尽管脊柱固定系统和IVD置换技术取得了进展，但在保留生理运动的同时实现长期节段稳定性仍然是一项重大挑战。为克服这一问题，本研究旨在通过严格分析确定人工IVD植入物的生物力学特性。最终目标是提供信息，以探索设计和开发与脊柱无缝整合的新型植入物，恢复自然脊柱功能并提供长期、可持续的承重特性，模拟天然IVD的弹性和寿命。为解决所有这些问题，我们对文献进行了全面综述，根据身体结构、相关疾病、生物力学和各种IVD发育模型整理研究结果。目前的工作涉及批判性分析，旨在为未来新型IVD植入物的设计和开发提供参考。
