Centre for Global Mental Health, Health Service and Population Research Department, Institute of Psychiatry, P060, De Crespigny Park, London SE58AF, UK.
BMC Public Health. 2010 Jun 23;10:366. doi: 10.1186/1471-2458-10-366.
Eighty percent of deaths occur in low and middle income countries (LMIC), where chronic diseases are the leading cause. Most of these deaths are of older people, but there is little information on the extent, pattern and predictors of their mortality. We studied these among people aged 65 years and over living in urban catchment areas in Chennai, south India.
In a prospective population cohort study, 1005 participants were followed-up after three years. Baseline assessment included sociodemographic and socioeconomic characteristics, health behaviours, physical, mental and cognitive disorders, disability and subjective global health.
At follow-up, 257 (25.6%) were not traced. Baseline characteristics were similar to the 748 whose vital status was ascertained; 154 (20.6%) had died. The mortality rate was 92.5/1,000 per annum for men and 51.0/1,000 per annum for women. Adjusting for age and sex, mortality was associated with older age, male sex, having no friends, physical inactivity, smaller arm circumference, dementia, depression, poor self-rated health and disability. A parsimonious model included, in order of aetiologic force, male sex, smaller arm circumference, age, disability, and dementia. The total population attributable risk fraction was 0.90.
A balanced approach to prevention of chronic disease deaths requires some attention to proximal risk factors in older people. Smoking and obesity seem much less relevant than in younger people. Undernutrition is preventable. While dementia makes the largest contribution to disability and dependency, comorbidity is the rule, and more attention should be given to the chronic care needs of those affected, and their carers.
80%的死亡发生在中低收入国家(LMIC),这些国家的慢性病是主要死因。这些死亡大多数发生在老年人身上,但关于他们的死亡率的程度、模式和预测因素的信息很少。我们在印度南部钦奈的城市集水区中研究了年龄在 65 岁及以上的人群。
在一项前瞻性人群队列研究中,对 1005 名参与者进行了三年的随访。基线评估包括社会人口统计学和社会经济特征、健康行为、身体、心理和认知障碍、残疾和主观整体健康状况。
随访时,257 人(25.6%)无法追踪。基线特征与确定其生命状态的 748 人相似;有 154 人(20.6%)死亡。男性的死亡率为 92.5/1000 人年,女性的死亡率为 51.0/1000 人年。调整年龄和性别后,死亡率与年龄较大、男性、没有朋友、身体不活动、手臂周长较小、痴呆、抑郁、自我报告健康状况较差和残疾有关。一个简约模型按病因力的顺序包括男性、手臂周长较小、年龄、残疾和痴呆。总人口归因风险分数为 0.90。
预防慢性病死亡需要平衡关注老年人的近端危险因素。与年轻人相比,吸烟和肥胖的相关性似乎要小得多。营养不良是可以预防的。虽然痴呆症对残疾和依赖的贡献最大,但合并症是常见的,应该更加关注受影响者及其照顾者的慢性病护理需求。