Severtson Stevan G, Hedden Sarra L, Martins Silvia S, Latimer William W
University of Pittsburg, PA, USA.
Johns Hopkins Bloomberg School of Public Health-Mental Health, Baltimore, MD, USA.
J Learn Disabil. 2012 Mar-Apr;45(2):139-50. doi: 10.1177/0022219409355481. Epub 2010 Jun 23.
This study used data from six neuropsychological measures of executive function (EF) and general intellectual functioning (GIF) administered to 303 regular users of heroin and/or cocaine as indicators in a latent profile analysis (LPA). Results indicated the presence of three profiles: impaired GIF and EF profile (30.8%), intact GIF and EF profile (58.8%), and high GIF/intact EF profile (10.4%). Using a multinomial logistic regression, it was determined that individuals who reported being diagnosed with either a learning disability (LD) and/or attention-deficit/hyperactivity disorder (ADHD) were more likely to be in the impaired GIF and EF profile than other profiles. Results from a logistic regression indicated that the impaired GIF and EF profile was associated with a greater prevalence of past hepatitis B and/or C infection. Implication for harm reduction and treatment programs and the need to take into account individuals with LD and ADHD are discussed.
本研究使用了对303名海洛因和/或可卡因常规使用者进行的六项执行功能（EF）和一般智力功能（GIF）神经心理学测量数据，作为潜在剖面分析（LPA）中的指标。结果表明存在三种剖面：GIF和EF受损剖面（30.8%）、GIF和EF完整剖面（58.8%）以及高GIF/EF完整剖面（10.4%）。通过多项逻辑回归分析确定，报告被诊断患有学习障碍（LD）和/或注意力缺陷多动障碍（ADHD）的个体比其他剖面的个体更有可能处于GIF和EF受损剖面。逻辑回归结果表明，GIF和EF受损剖面与过去乙型和/或丙型肝炎感染的较高患病率相关。讨论了对减少伤害和治疗项目的启示以及考虑LD和ADHD个体的必要性。
