设计、合成及包含立体规整和无环聚碳酸酯骨架的核酸的 DNA/RNA 结合研究：聚碳酸酯核酸（PCNA）。
Design, synthesis and DNA/RNA binding studies of nucleic acids comprising stereoregular and acyclic polycarbamate backbone: polycarbamate nucleic acids (PCNA).
机构信息
Division of Organic Chemistry, National Chemical Laboratory, Pune 411008, India.
出版信息
Org Biomol Chem. 2010 Aug 21;8(16):3734-41. doi: 10.1039/c003405n. Epub 2010 Jun 24.
DOI:10.1039/c003405n
PMID:20574572
Abstract
The designed, chiral, acyclic polycarbamate nucleic acids (PCNA) exhibited sequence and orientation specific binding to nucleic acids. Complexes of PCNA with DNA were as stable as PNA:DNA complexes and those with RNA were as stable as natural DNA:RNA complexes.
摘要
设计的手性非环多聚碳酸酯核酸（PCNA）表现出序列和方向特异性与核酸结合。PCNA 与 DNA 的复合物与 PNA:DNA 复合物一样稳定，与 RNA 的复合物与天然 DNA:RNA 复合物一样稳定。
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