CSIRO Materials Science and Engineering, P.O. Box 218, Lindfield, NSW 2070, Australia.
J Biophotonics. 2011 Apr;4(4):244-51. doi: 10.1002/jbio.201000056.
Diagnostic catheters based on fibre Bragg gratings (FBG's) are proving to be highly effective for measurement of the muscular activity associated with motility in the human gut. While the primary muscular contractions that generate peristalsis are circumferential in nature, it has long been known that there is also a component of longitudinal contractility present, acting in harmony with the circumferential component to improve the overall efficiency of material movement. We report the detection of longitudinal motion in mammalian intestine using an FBG technique that should be viable for similar detection in humans. The longitudinal sensors have been combined with our previously reported FBG pressure sensing elements to form a composite catheter that allows the relative phase between the two components to be detected. The catheter output has been validated using video mapping in an ex-vivo rabbit ileum preparation.
基于光纤布拉格光栅(FBG)的诊断导管被证明在测量与人类肠道蠕动相关的肌肉活动方面非常有效。虽然产生蠕动的主要肌肉收缩是环形的,但长期以来人们一直知道,也存在纵向收缩性的成分,与环形成分协同作用,以提高物质运动的整体效率。我们使用 FBG 技术报告了在哺乳动物肠道中检测到的纵向运动,该技术应该可用于在人类中进行类似的检测。纵向传感器与我们之前报道的 FBG 压力感应元件相结合,形成了一种复合导管,可检测两个组件之间的相对相位。导管输出已使用离体兔回肠制备物中的视频映射进行了验证。