Ali B H, Tanira M O, Bashir A K
Desert and Marine Environment Research Centre, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Eur J Drug Metab Pharmacokinet. 1996 Oct-Dec;21(4):327-32. doi: 10.1007/BF03189734.
This work examines the effect of oral treatment of rats with the nitrofuran drugs furazolidone (FZ) and furaltadone (F) at doses of 100, 200 and 400 mg/kg for 4 days, or F in the drinking water at concentrations of 0.1, 0.2 and 0.4% w/v for 14 days, on drug metabolism in vivo. FZ at doses of 200 and 400 mg/kg, and F at a dose of 400 mg/kg or at a concentration of 0.4% w/v in water depressed growth and prolonged pentobarbitone-induced sleeping time. Treatment also significantly increased the blood concentration of metronidazole when measured 30 and 40 min after metronidazole administration. Administration of tremorine (25 mg/kg, i.p.) to control vehicle-treated rats produced within 2-3 min tremors, piloerection, profuse salivation, defecation urination and chromodacryorrhesis (red tears). The onset of appearance of these signs was delayed to 7-12 min in rats pretreated with FZ or F (100 mg/kg, 4 days) or cimetidine (50 mg/kg, i.p.) given 45 min earlier. Taken together, these results suggest that FZ and F inhibit drug metabolism in rats. Treatment with these nitrofuran drugs may alter the disposition of certain drugs which may be given concomitantly with them.
本研究考察了以100、200和400mg/kg的剂量给大鼠口服硝基呋喃类药物呋喃唑酮（FZ）和呋喃它酮（F）4天，或以0.1、0.2和0.4%w/v的浓度将F添加到饮用水中给大鼠饮用14天，对大鼠体内药物代谢的影响。200和400mg/kg剂量的FZ，以及400mg/kg剂量或0.4%w/v浓度的F可抑制大鼠生长，并延长戊巴比妥诱导的睡眠时间。在甲硝唑给药后30和40分钟测量时，给药处理还显著提高了甲硝唑的血药浓度。给用赋形剂处理的对照大鼠腹腔注射震颤素（25mg/kg）后2 - 3分钟内会出现震颤、竖毛、大量流涎、排便、排尿和流泪（红泪）。在用FZ或F（100mg/kg，4天）预处理的大鼠中，或在45分钟前给予西咪替丁（50mg/kg，腹腔注射）的大鼠中，这些体征出现的起始时间延迟至7 - 12分钟。综上所述，这些结果表明FZ和F可抑制大鼠的药物代谢。用这些硝基呋喃类药物进行治疗可能会改变某些与之同时给药的药物的处置情况。
