Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec Canada.
Addict Biol. 1999 Apr;4(2):215-21. doi: 10.1080/13556219971731.
Direct descendants of an individual residing in Israel, who was diagnosed in the 1960s with a genetic deficiency in catalase, were examined for their propensity to consume alcohol.These individuals were found to possess a lower level of catalase activity compared to that of a group of matched controls with the same ethnic background.While no differences were observed in the propensity to drink alcohol between the two groups, the catalase deficient individuals did show a significant positive correlation between catalase activity and alcohol drinking behaviour as measured by Q-value. No such relationship was observed in the matched controls.The findings suggest that the apparent acatalasemia in the experimental subjects may act as a limiting factor for these individuals and that catalase may play an important role in regulating alcohol drinking behaviour. These results are consistent with previous animal and human studies which suggest that catalase, via its ability to produce acetaldehyde through the metabolism of ethanol, may have a regulatory role in the propensity to drink alcohol.
居住在以色列的个体，在 20 世纪 60 年代被诊断出存在过氧化氢酶遗传缺陷，其直系后代的酒精摄入倾向接受了检查。这些个体的过氧化氢酶活性水平明显低于具有相同种族背景的一组匹配对照组。尽管两组个体的饮酒倾向没有差异，但在通过 Q 值衡量的情况下，过氧化氢酶缺乏个体的过氧化氢酶活性与饮酒行为之间存在显著正相关。在匹配对照组中未观察到这种关系。研究结果表明，实验对象中明显的非过氧化氢酶血症可能是这些个体的限制因素，过氧化氢酶可能在调节饮酒行为方面发挥重要作用。这些结果与先前的动物和人体研究一致，该研究表明，过氧化氢酶通过其代谢乙醇产生乙醛的能力，可能在饮酒倾向方面发挥调节作用。
