Marin Cristina, Fernández Eduardo
Institute of Bioengineering, University Miguel Hernández Elche, Spain.
Front Neuroeng. 2010 May 28;3:8. doi: 10.3389/fneng.2010.00008. eCollection 2010.
Rehabilitation of sensory and/or motor functions in patients with neurological diseases is more and more dealing with artificial electrical stimulation and recording from populations of neurons using biocompatible chronic implants. As more and more patients have benefited from these approaches, the interest in neural interfaces has grown significantly. However an important problem reported with all available microelectrodes to date is long-term viability and biocompatibility. Therefore it is essential to understand the signals that lead to neuroglial activation and create a targeted intervention to control the response, reduce the adverse nature of the reactions and maintain an ideal environment for the brain-electrode interface. We discuss some of the exciting opportunities and challenges that lie in this intersection of neuroscience research, bioengineering, neurology and biomaterials.
神经疾病患者感觉和/或运动功能的康复越来越多地涉及使用生物相容性慢性植入物对神经元群体进行人工电刺激和记录。随着越来越多的患者从这些方法中受益，对神经接口的兴趣显著增加。然而，迄今为止，所有可用的微电极都存在一个重要问题，即长期生存能力和生物相容性。因此，了解导致神经胶质激活的信号并进行有针对性的干预以控制反应、减少反应的不良性质并为脑电极界面维持理想环境至关重要。我们讨论了神经科学研究、生物工程、神经病学和生物材料这一交叉领域中存在的一些令人兴奋的机遇和挑战。
