Department of Emergency Medical Science, Kanazawa University Graduate School of Medicine, 13-1 Takaramachi, Kanazawa 920-8641, Japan.
J Anesth. 2010 Oct;24(5):716-25. doi: 10.1007/s00540-010-0974-6. Epub 2010 Jun 25.
It is not clear whether advanced airway management (AAM) with an endotracheal tube (ET) by paramedics may improve the outcome of out-of-hospital cardiac arrest (OHCA) compared with the use of a bag-valve-mask device (BVMD) and other AAM devices.
We analyzed 2,586 adult cases of OHCA without administration of adrenaline, witnessed or recognized by citizens in subjects transported to hospital by paramedics between 1 July 2004 and 31 March 2008 in Ishikawa, Japan, to determine whether AAM with an ET used under limited indication criteria may improve the outcome of OHCA.
The airway was managed with an ET in 263 cases, other AAM devices in 660 cases, and a BVMD in 1,539 cases. The AAM failed or was discontinued in 124 cases, which were excluded from the analysis. The incidence of sustained return of spontaneous circulation (ROSC) was significantly higher in cases of AAM with an ET (30%) than in AAM with other devices (20.2%) and in the standard procedure with a BVMD (21.3%). The AAM with an ET did not significantly affect 1-year survival. Multiple regression analysis indicated that tracheal intubation (odds ratio = 1.503, 95% confidence interval 1.081-2078), but not patient management by paramedics qualified for ET use, was an independent factor associated with sustained ROSC.
When subjects with difficult airway are excluded, tracheal intubation according to the limited indication criteria and well-organized protocol in Japan may improve the short-term outcome of OHCA of noncardiac origin. A large prospective study is needed to determine the general effects of tracheal intubation on the long-term outcome of OHCA with disturbed ventilation.
目前尚不清楚与使用球囊面罩装置(BVMD)和其他高级气道管理(AAM)设备相比,急救人员进行气管内插管(ET)的 AAM 是否能改善院外心脏骤停(OHCA)的结局。
我们分析了 2004 年 7 月 1 日至 2008 年 3 月 31 日期间,日本石川县急救人员转运至医院的 2586 例无肾上腺素治疗、由市民目击或识别的成人 OHCA 病例,以确定在有限适应证标准下使用 ET 进行 AAM 是否能改善 OHCA 的结局。
263 例采用 ET 进行气道管理,660 例采用其他 AAM 设备,1539 例采用 BVMD。124 例 AAM 失败或中断,这些病例被排除在分析之外。ET 组自主循环恢复(ROSC)的持续发生率(30%)明显高于其他 AAM 设备组(20.2%)和标准 BVMD 组(21.3%)。ET 组的 1 年生存率无显著差异。多因素回归分析表明,气管插管(优势比=1.503,95%置信区间 1.081-2078)而非急救人员的患者管理是与持续 ROSC 相关的独立因素。
排除存在困难气道的患者后,根据日本的有限适应证标准和规范的方案进行气管内插管可能会改善非心源性 OHCA 的短期结局。需要进行大型前瞻性研究来确定气管插管对通气障碍的 OHCA 长期结局的普遍影响。