人类条件位置：转化研究的机会。
Place conditioning in humans: opportunities for translational research.
机构信息
Department of Neurobiology and Institute for Neuroscience, University of Chicago, Chicago, IL, 60637, USA.
Department of Psychology, University of Nebraska - Lincoln, Lincoln, NE, 68588-0308, USA.
出版信息
Psychopharmacology (Berl). 2023 Nov;240(11):2221-2230. doi: 10.1007/s00213-023-06316-8. Epub 2023 Jan 19.
RATIONALE
Translational research, especially research that bridges studies with humans and nonhuman species, is critical to advancing our understanding of human disorders such as addiction. This advancement requires reliable and rigorous models to study the underlying constructs contributing to the maladaptive behavior.
OBJECTIVE
In this commentary, we address some of the challenges of conducting translational research by examining a single procedure, place conditioning. Place conditioning is commonly used with laboratory animals to study the conditioned rewarding effects of drugs, and recent studies indicate that a similar procedure can be used in humans.
RESULTS
We discuss the opportunities and challenges of making the procedure comparable across species, as well as discuss the benefits of more systematically applying the procedure to humans.
CONCLUSION
We argue that the capacity of humans to report verbally on their internal experiences (perceptions, affective states, likes and dislikes) add an important dimension to the understanding of the procedures used in laboratory animals.
理由
转化研究，特别是连接人类和非人类物种研究的转化研究，对于增进我们对人类疾病（如成瘾）的理解至关重要。这种进步需要可靠和严格的模型来研究导致适应不良行为的潜在结构。
目的
在这篇评论中，我们通过检查一个单一的程序——位置条件作用，来解决转化研究中的一些挑战。位置条件作用通常用于实验室动物来研究药物的条件性奖励效应，最近的研究表明，类似的程序可以在人类中使用。
结果
我们讨论了使该程序在物种间具有可比性的机会和挑战，以及更系统地将该程序应用于人类的益处。
结论
我们认为，人类能够口头报告其内部体验（感知、情感状态、喜好和厌恶）的能力为理解实验室动物中使用的程序增加了一个重要的维度。
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