Noda A
Third Department of Internal Medicine, Aichi Medical University, Japan.
Trop Gastroenterol. 1991 Jan-Mar;12(1):3-14.
It has been known that intrahepatic biliary lithiasis (IHBL) is prevalent in East Asia including Japan, South Korea, Taiwan, Malaysia, Hong Kong, and Singapore. In contrast, the entity has drawn little attention in Europe and the United States where only scattered reports appear. IHBL can be placed in the category of the benign disease. Its distinctive clinical picture is an intractable course necessitating multiple surgical interventions because recurrence is usual, rather than exceptional. This is in distinct contrast to ordinal stones which originate in the gallbladder. Patients with IHBL do not rarely die of progressive hepatic damage resulting from longstanding obstructive jaundice, cholangitis, liver abscess, septicemia, and so forth.
众所周知，肝内胆管结石（IHBL）在包括日本、韩国、台湾、马来西亚、香港和新加坡在内的东亚地区较为普遍。相比之下，该疾病在欧洲和美国很少受到关注，仅有零星报道。IHBL可归类为良性疾病。其独特的临床表现是病程顽固，由于复发常见而非罕见，往往需要多次手术干预。这与起源于胆囊的普通结石形成鲜明对比。患有IHBL的患者不乏死于长期梗阻性黄疸、胆管炎、肝脓肿、败血症等导致的进行性肝损伤。
