白塞病复发性口腔溃疡中热休克蛋白60的表达

HSP 60 expression in recurrent oral ulcerations of Behçet's disease.

作者信息

Deniz Ediz, Guc Ulker, Buyukbabani Nesimi, Gul Ahmet

机构信息

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Yeditepe University, Istanbul, Turkey.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Aug;110(2):196-200. doi: 10.1016/j.tripleo.2010.03.020. Epub 2010 Jun 26.

DOI:10.1016/j.tripleo.2010.03.020

PMID:20580281

Abstract

OBJECTIVE

The aim was to investigate heat shock protein 60 (HSP60) expression in oral ulcerations of Behçet's disease (BD).

STUDY DESIGN

Biopsy specimens were obtained from patients with BD (n = 11), recurrent aphthous stomatitis (RAS) (n = 11), oral lichen planus (OLP) (n = 11) and healthy individuals (HI) (n = 11). Eight samples in BD and RAS groups were evaluable. All groups were analyzed by biotin streptavidin-aminoethylcarbazole using monoclonal mouse antibodies to HSP60 Ab-1 (clone LK1).

RESULTS

Immunostaining indicative of HSP60 expression in BD and RAS were significantly higher than HI. No significant difference was found between BD and OLP except in the suprabasal layer of epithelium.

CONCLUSIONS

Altered expression of HSP60 was found in ulcerative lesions of BD and RAS suggesting that HSP60 has an association with the etiology or chronicity of these inflammatory lesions.

摘要

目的

旨在研究白塞病（BD）口腔溃疡中热休克蛋白60（HSP60）的表达情况。

研究设计

从BD患者（n = 11）、复发性阿弗他口炎（RAS）患者（n = 11）、口腔扁平苔藓（OLP）患者（n = 11）和健康个体（HI）（n = 11）获取活检标本。BD组和RAS组有8个样本可评估。所有组均使用抗HSP60 Ab-1（克隆LK1）的单克隆小鼠抗体通过生物素链霉亲和素-氨基乙基咔唑进行分析。