紫羊蹄甲叶提取物对大鼠伤口愈合潜力的评估。
Evaluation of Wound Healing Potential of Bauhinia purpurea Leaf Extracts in Rats.
作者信息
Ananth K V, Asad M, Prem Kumar N, Asdaq S M B, Rao G S
机构信息
Department of Pharmacology, Krupanidhi College of Pharmacy, Chikkabellandur, Carmelaram post, Varthur Hobli, Bangalore-560 035, India.
出版信息
Indian J Pharm Sci. 2010 Jan;72(1):122-7. doi: 10.4103/0250-474X.62250.
The present study was carried out to evaluate the effect of methanol and chloroform extracts of Bauhinia purpurea on experimentally induced excision, incision, burn and dead space wound models in Sprague Dawley rats. Formulations of methanol and chloroform extracts of Bauhinia purpurea were prepared in carbopol and simple ointment base at concentrations of 2.5% and 5% and applied to the wounds. In the excision and burn wound models, animals treated with high doses of methanol and chloroform showed significant reduction in time taken for epithelization and wound contraction (50%) compared to control. A significant increase in breaking strength was found in incision wound model with methanol and chloroform extracts compared to their respective bases. In the dead space wound model, methanol and chloroform extract treatment (100 and 500 mg/kg) orally produced a significant increase in the breaking strength, dry tissue weight and hydroxyproline content of the granulation tissue when compared to control. Among the extracts, methanol extract exhibited more activity followed by the chloroform extract. In conclusion, the present study indicated that Bauhinia purpurea leaves exhibited wound healing activity.
本研究旨在评估紫羊蹄甲甲醇提取物和氯仿提取物对实验诱导的Sprague Dawley大鼠切除、切开、烧伤和死腔伤口模型的影响。将紫羊蹄甲甲醇提取物和氯仿提取物分别以2.5%和5%的浓度制备于卡波姆和简单软膏基质中，并应用于伤口。在切除和烧伤伤口模型中，与对照组相比，高剂量甲醇提取物和氯仿提取物处理的动物上皮化时间和伤口收缩率（50%）显著降低。在切开伤口模型中，与各自的基质相比，甲醇提取物和氯仿提取物处理的动物的抗张强度显著增加。在死腔伤口模型中，与对照组相比，口服甲醇提取物和氯仿提取物（100和500mg/kg）可显著提高肉芽组织的抗张强度、干组织重量和羟脯氨酸含量。在提取物中，甲醇提取物的活性更强，其次是氯仿提取物。总之，本研究表明紫羊蹄甲叶具有伤口愈合活性。
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