Huttenlocher P R, Amemiya I M
Pediatr Res. 1978 Feb;12(2):104-7. doi: 10.1203/00006450-197802000-00008.
The effect of cortisol, methylprednisolone, and ACTH on (Na+-K+)-ATPase activity in developing cerebral cortex has been measured. Stimulation of (Na+-K+)-ATPase by these agents has been found in whole brain homogenates of kittens as early as age 8 days, and in whole homogenates and light microsomal fractions in young rats at 14 and 28 days. (Na+-K+)-ATPase activity in animals treated with corticosteroids or ACTH for 4 days was found to be 15--30% higher than activity in littermate controls. Brain potassium concentrations was increased in 14-day-old rats treated with methylprednisolone.
已测定皮质醇、甲泼尼龙和促肾上腺皮质激素对发育中大脑皮质（钠 - 钾）-ATP酶活性的影响。早在8日龄小猫的全脑匀浆中，以及14日龄和28日龄幼鼠的全匀浆和轻微粒体组分中，就已发现这些药物对（钠 - 钾）-ATP酶有刺激作用。用皮质类固醇或促肾上腺皮质激素处理4天的动物，其（钠 - 钾）-ATP酶活性比同窝对照动物高15% - 30%。用甲泼尼龙处理的14日龄大鼠脑钾浓度有所增加。
