疟疾和结核病的广泛耐药性。
Extensive drug resistance in malaria and tuberculosis.
机构信息
US Agency for International Development, Bangkok 10330, Thailand.
出版信息
Emerg Infect Dis. 2010 Jul;16(7):1063-7. doi: 10.3201/eid1607.091840.
Abstract
Drug resistance in malaria and in tuberculosis (TB) are major global health problems. Although the terms multidrug-resistant TB and extensively drug-resistant TB are precisely defined, the term multidrug resistance is often loosely used when discussing malaria. Recent declines in the clinical effectiveness of antimalarial drugs, including artemisinin-based combination therapy, have prompted the need to revise the definitions of and/or to recategorize antimalarial drug resistance to include extensively drug-resistant malaria. Applying precise case definitions to different levels of drug resistance in malaria and TB is useful for individual patient care and for public health.
摘要
抗药性在疟疾和结核病（TB）中是主要的全球健康问题。虽然多药耐药结核病和广泛耐药结核病的术语有明确的定义，但在讨论疟疾时，多药耐药性这个术语经常被不严格地使用。最近，包括青蒿素联合疗法在内的抗疟药物的临床疗效下降，促使人们需要修订抗疟药物耐药性的定义和/或重新分类，以将广泛耐药性疟疾包括在内。在疟疾和结核病的不同耐药水平上应用精确的病例定义，对个体患者的护理和公共卫生都很有用。
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