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马尔堡病毒感染的暴露后治疗。

Postexposure treatment of Marburg virus infection.

机构信息

National Emerging Infectious Diseases Laboratories Institute, Boston, Massachusetts 02118, USA.

出版信息

Emerg Infect Dis. 2010 Jul;16(7):1119-22. doi: 10.3201/eid1607.100159.

DOI:10.3201/eid1607.100159
PMID:20587184
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3321919/
Abstract

Rhesus monkeys are protected from disease when a recombinant vesicular stomatitis virus-based vaccine is administered 20-30 min after infection with Marburg virus. We protected 5/6 monkeys when this vaccine was given 24 h after challenge; 2/6 animals were protected when the vaccine was administered 48 h postinfection.

摘要

当重组单纯疱疹病毒基于疫苗在感染马尔堡病毒后 20-30 分钟给予时，恒河猴可免受疾病侵害。当这种疫苗在挑战后 24 小时给予时，我们保护了 5/6 的猴子；当疫苗在感染后 48 小时给予时，2/6 的动物受到保护。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1741/3321919/b3ff1e679c05/10-0159-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1741/3321919/b3ff1e679c05/10-0159-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1741/3321919/b3ff1e679c05/10-0159-F.jpg

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Managing potential laboratory exposure to ebola virus by using a patient biocontainment care unit.通过使用患者生物防护护理单元来管理实验室潜在的埃博拉病毒暴露风险。
Emerg Infect Dis. 2008 Jun;14(6):881-7. doi: 10.3201/eid1406.071489.
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Recombinant vesicular stomatitis virus vector mediates postexposure protection against Sudan Ebola hemorrhagic fever in nonhuman primates.
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Viruses. 2024 Jul 24;16(8):1181. doi: 10.3390/v16081181.
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An update on nonhuman primate usage for drug and vaccine evaluation against filoviruses.关于用于评估抗丝状病毒药物和疫苗的非人类灵长类动物使用的最新进展。
Expert Opin Drug Discov. 2024 Oct;19(10):1185-1211. doi: 10.1080/17460441.2024.2386100. Epub 2024 Aug 18.
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