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通过使用患者生物防护护理单元来管理实验室潜在的埃博拉病毒暴露风险。

Managing potential laboratory exposure to ebola virus by using a patient biocontainment care unit.

作者信息

Kortepeter Mark G, Martin James W, Rusnak Janice M, Cieslak Theodore J, Warfield Kelly L, Anderson Edwin L, Ranadive Manmohan V

机构信息

US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.

出版信息

Emerg Infect Dis. 2008 Jun;14(6):881-7. doi: 10.3201/eid1406.071489.

DOI:10.3201/eid1406.071489
PMID:18507897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2600302/
Abstract

In 2004, a scientist from the US Army Medical Research Institute of Infectious Diseases (USAMRIID) was potentially exposed to a mouse-adapted variant of the Zaire species of Ebola virus. The circumstances surrounding the case are presented, in addition to an update on historical admissions to the medical containment suite at USAMRIID. Research facilities contemplating work with pathogens requiring Biosafety Level 4 laboratory precautions should be mindful of the occupational health issues highlighted in this article.

摘要

2004年,美国陆军传染病医学研究所(USAMRIID)的一名科学家可能接触到了扎伊尔埃博拉病毒的小鼠适应变种。除了对USAMRIID医疗隔离病房的历史收治情况进行更新外,还介绍了该病例的相关情况。考虑开展需要生物安全4级实验室防护措施的病原体研究工作的研究机构,应留意本文所强调的职业健康问题。

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本文引用的文献

1
Designing a biocontainment unit to care for patients with serious communicable diseases: a consensus statement.设计用于护理严重传染病患者的生物安全隔离单元:一份共识声明。
Biosecur Bioterror. 2006;4(4):351-65. doi: 10.1089/bsp.2006.4.351.
2
A DNA vaccine for Ebola virus is safe and immunogenic in a phase I clinical trial.一种针对埃博拉病毒的DNA疫苗在I期临床试验中是安全且具有免疫原性的。
Clin Vaccine Immunol. 2006 Nov;13(11):1267-77. doi: 10.1128/CVI.00162-06. Epub 2006 Sep 20.
3
Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference.RNA干扰可使豚鼠在接触埃博拉病毒后获得针对致死性病毒攻击的保护。
J Infect Dis. 2006 Jun 15;193(12):1650-7. doi: 10.1086/504267. Epub 2006 May 10.
4
Immune protection of nonhuman primates against Ebola virus with single low-dose adenovirus vectors encoding modified GPs.用编码修饰糖蛋白的单低剂量腺病毒载体对非人灵长类动物进行埃博拉病毒免疫保护。
PLoS Med. 2006 Jun;3(6):e177. doi: 10.1371/journal.pmed.0030177. Epub 2006 May 16.
5
Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers.基于反义磷酰二胺吗啉代寡聚物的针对埃博拉病毒的基因特异性对策。
PLoS Pathog. 2006 Jan;2(1):e1. doi: 10.1371/journal.ppat.0020001. Epub 2006 Jan 13.
6
Antisense oligonucleotides: the state of the art.反义寡核苷酸:当前技术水平
Curr Med Chem. 2005;12(19):2193-214. doi: 10.2174/0929867054864859.
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8
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Experience in the medical management of potential laboratory exposures to agents of bioterrorism on the basis of risk assessment at the United States Army Medical Research Institute of Infectious Diseases (USAMRIID).美国陆军传染病医学研究所(USAMRIID)基于风险评估对潜在实验室暴露于生物恐怖主义制剂进行医学管理的经验。
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