Strand Douglas W, Hayward Simon W
Division of Urologic Surgery, Vanderbilt University, 1161 21st Avenue S, Nashville, TN 37232, USA.
Discov Med. 2010 Jun;9(49):504-11.
The role of tumor stroma in progression to malignancy has become the subject of intense experimental and clinical interest. The stromal compartment of organs is composed of all the non-epithelial cell types and maintains the proper architecture and nutrient levels required for epithelial and, ultimately, organ function. The composition of the reactive stroma surrounding tumors is vastly different from normal stromal tissue. Stromal phenotype can be correlated with, and predictive of, disease recurrence. In addition, the stroma is now seen as a legitimate target for therapeutic intervention. Although much has been learned about the role of the stromal compartment in development and disease in recent years, a number of key questions remain. Here we review how some of these questions are beginning to be addressed using new models of stromal-epithelial interaction.
肿瘤基质在恶性进展中的作用已成为实验和临床研究的热点。器官的基质部分由所有非上皮细胞类型组成，维持上皮组织乃至器官功能所需的适当结构和营养水平。肿瘤周围反应性基质的组成与正常基质组织有很大不同。基质表型与疾病复发相关且可预测疾病复发。此外，现在认为基质是治疗干预的合理靶点。尽管近年来对基质部分在发育和疾病中的作用已有很多了解，但仍有一些关键问题存在。在此，我们综述如何开始使用基质-上皮相互作用的新模型来解决其中一些问题。
