Department of Mathematics, University of Vienna, Vienna, Austria.
Bioinformatics. 2010 Aug 15;26(16):2064-5. doi: 10.1093/bioinformatics/btq322. Epub 2010 Jun 30.
We have implemented a coalescent simulation program for a structured population with selection at a single diploid locus. The program includes the functionality of the simulator ms to model population structure and demography, but adds a model for deme- and time-dependent selection using forward simulations. The program can be used, e.g. to study hard and soft selective sweeps in structured populations or the genetic footprint of local adaptation. The implementation is designed to be easily extendable and widely deployable. The interface and output format are compatible with ms. Performance is comparable even with selection included.
The program is freely available from http://www.mabs.at/ewing/msms/ along with manuals and examples. The source is freely available under a GPL type license.
我们已经为具有单一二倍体基因座选择的结构群体实现了一个合并模拟程序。该程序包括模拟器 ms 的功能，用于模拟群体结构和人口统计学，但添加了一个使用正向模拟的种群和时间相关选择模型。该程序可用于研究结构群体中的硬选择和软选择 sweep 或局部适应的遗传痕迹。该实现旨在易于扩展和广泛部署。接口和输出格式与 ms 兼容。即使包含选择，性能也相当。
该程序可从 http://www.mabs.at/ewing/msms/ 免费获得，同时提供手册和示例。源代码可根据 GPL 类型许可证免费获得。
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