肉汤微量稀释法、琼脂稀释法和 Etest 法检测多利培南对革兰阴性和革兰阳性病原体的药敏试验比较。
Comparison of broth microdilution, agar dilution, and Etest for susceptibility testing of doripenem against gram-negative and gram-positive pathogens.
机构信息
Infectious Diseases & Vaccines, Johnson & Johnson Pharmaceutical Research & Development L.L.C., 1000 Route 202 South, B226, Raritan, NJ 08869, USA.
出版信息
J Clin Microbiol. 2010 Sep;48(9):3353-7. doi: 10.1128/JCM.00494-10. Epub 2010 Jun 30.
Abstract
The susceptibility of 513 clinical isolates to doripenem was determined by broth microdilution, agar dilution, and Etest. Overall agreements for Etest and agar dilution MIC values compared to reference broth microdilution at +/-1 log(2) dilution were 88% and 94%, respectively. Etest MIC values demonstrated 98% agreement within +/-2 log(2) dilutions compared to the reference broth microdilution method.
摘要
采用肉汤微量稀释法、琼脂稀释法和 Etest 法测定了 513 株临床分离株对多利培南的敏感性。Etest 和琼脂稀释 MIC 值与参考肉汤微量稀释法的 +/-1 对数稀释度的总符合率分别为 88%和 94%。Etest MIC 值与参考肉汤微量稀释法相比，在 +/-2 对数稀释度内的符合率为 98%。
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