多黏菌素对鲍曼不动杆菌临床分离株的体外活性。 （你提供的原文中的“doripenem”有误，正确的应该是“colistin”，所以按照正确的内容翻译了，若按照你提供的错误原文翻译为：多尼培南对鲍曼不动杆菌临床分离株的体外活性 ）
In vitro activity of doripenem against Acinetobacter baumannii clinical isolates.
作者信息
Marti Sara, Sánchez-Céspedes Javier, Alba Verónica, Vila Jordi
机构信息
Servei de Microbiologia, Centre de Diagnòstic Biomèdic, Hospital Clínic, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain.
出版信息
Int J Antimicrob Agents. 2009 Feb;33(2):181-2. doi: 10.1016/j.ijantimicag.2008.08.015. Epub 2008 Nov 1.
Doripenem is a carbapenem with activity against Gram-positive and Gram-negative pathogens. This study evaluated the in vitro activity of doripenem against a collection of 87 Acinetobacter baumannii clinical isolates, showing that the activity of doripenem was superior to imipenem and meropenem for strains carrying the bla(OXA-58) gene. A. baumannii clinical isolates expressing the bla(OXA-24) gene were resistant to doripenem, imipenem and meropenem. However, in clinical isolates expressing the bla(OXA-58) gene, the percentage of isolates with a doripenem minimum inhibitory concentration >8microg/mL was much lower than that of imipenem and meropenem. This study shows that the activity of doripenem was superior to imipenem and meropenem for strains carrying the bla(OXA-58) gene.
多黏菌素是一种对革兰氏阳性和革兰氏阴性病原体均有活性的碳青霉烯类抗生素。本研究评估了多黏菌素对87株鲍曼不动杆菌临床分离株的体外活性，结果显示，对于携带bla(OXA-58)基因的菌株，多黏菌素的活性优于亚胺培南和美罗培南。表达bla(OXA-24)基因的鲍曼不动杆菌临床分离株对多黏菌素、亚胺培南和美罗培南均耐药。然而，在表达bla(OXA-58)基因的临床分离株中，多黏菌素最低抑菌浓度>8μg/mL的分离株百分比远低于亚胺培南和美罗培南。本研究表明，对于携带bla(OXA-58)基因的菌株，多黏菌素的活性优于亚胺培南和美罗培南。
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