前列腺癌患者的营养状况与饮食模式。

Nutritional status and eating pattern in prostate cancer patients.

作者信息

Mehdad A, McBride E, Monteiro Grillo I, Camilo M, Ravasco P

机构信息

Unidade de Nutrição e Metabolismo, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, and Serviço de Radioterapia, Hospital Universitario de Santa Maria, Lisboa, Portugal.

出版信息

Nutr Hosp. 2010 May-Jun;25(3):422-7.

PMID:20593125

Abstract

BACKGROUND

Prostate cancer is the second most common cancer in men worldwide. Differences in prostate cancer incidence suggest a significant role of environmental factors in the aetiology: obesity, central adiposity and some dietary factors have been suggested as risk factors. This pilot study aimed to analyse the pattern of nutritional status, body fat, and the usual dietary intake among men diagnosed with prostate cancer, consecutively referred to the Radiotherapy Department of the University Hospital Santa Maria.

PATIENTS & METHODS: Throughout 2006, 87 men with prostate cancer were included.

EVALUATIONS

weight & height to calculate body mass index (BMI), waist circumference, percentage body fat with bipolar hand-held bioimpedance analysis (BF-306), Food Frequency Questionnaire validated for the Portuguese population to assess the usual dietary intake. Frequency analysis and Mann-Whitney U test were used to evaluate prevalence and associations.

RESULTS

Mean age was 69+/-7 (46-85) years; 74 (84.1%) patients were in stage II, 5 (5.7%) in stage I & 9 (10.2%) in stage III; 39(45%) patients had a Gleason score>or=7. Regarding nutritional status, 78 (89%) patients were overweight/obese, 84 (97%) had a body fat above the maximum limit (>25%) and 43 (49%) had a waist circumference>102 cm (prevalence analysis: p<0.05). Univariate analysis did not show any association between Gleason Score, BMI, %body fat and waist circumference; by multivariate analysis there was an association between higher BMI, %body fat and aggressive Gleason scores (p<0.002), such variables worsened with age. Food frequency analysis showed a low consumption of n-3 fatty acids sources as well as vegetables and whole grain cereals and a correlation between low yogurt and vegetables intake with more aggressive Gleason scores was found (p<0.05).

CONCLUSION

Our findings show a high prevalence of obesity, excessive body and abdominal fat and diets deficient in protective nutrients. Further investigation is warranted as cancer rates in Portugal continue to increase!

摘要

背景

前列腺癌是全球男性中第二常见的癌症。前列腺癌发病率的差异表明环境因素在病因学中起着重要作用：肥胖、中心性肥胖和一些饮食因素被认为是风险因素。这项初步研究旨在分析连续转诊至圣玛丽亚大学医院放疗科的前列腺癌男性患者的营养状况、体脂和日常饮食摄入模式。

患者与方法

2006年全年，纳入了87名前列腺癌男性患者。

评估

测量体重和身高以计算体重指数（BMI）、腰围，使用双极手持式生物电阻抗分析仪（BF - 306）测量体脂百分比，使用针对葡萄牙人群验证的食物频率问卷评估日常饮食摄入。采用频率分析和曼 - 惠特尼U检验来评估患病率及相关性。

结果

平均年龄为69±7（46 - 85）岁；74例（84.1%）患者处于II期，5例（5.7%）处于I期，9例（10.2%）处于III期；39例（45%）患者的 Gleason评分≥7。关于营养状况，78例（89%）患者超重/肥胖，84例（97%）患者的体脂超过最大限值（>25%），43例（49%）患者的腰围>102 cm（患病率分析：p<0.05）。单因素分析未显示Gleason评分、BMI、体脂百分比和腰围之间存在任何关联；多因素分析显示较高的BMI、体脂百分比与侵袭性Gleason评分之间存在关联（p<0.002），这些变量随年龄增长而恶化。食物频率分析显示n - 3脂肪酸来源以及蔬菜和全谷物的摄入量较低，并且发现酸奶和蔬菜摄入量低与更具侵袭性的Gleason评分之间存在相关性（p<0.05）。