Cemek Mustafa, Büyükokuroğlu Mehmet Emin, Büyükben Ahmet, Aymelek Fatih, Yilmaz Fatma, Doğan Murat, Sanli Fatih, Uner Abdurrahman, Yildirim Derya
Department of Chemistry, Biochemistry Division, Faculty of Sciences and Arts, Afyon Kocatepe University, Afyonkarahisar, Turkey.
Pediatr Cardiol. 2010 Oct;31(7):1002-7. doi: 10.1007/s00246-010-9752-3. Epub 2010 Jul 1.
Acute rheumatic fever (ARF) is an autoimmune multisystem disease. Bio-elements are required in different quantities by an organism to maintain its physiologic function. Monitoring the status of bio-elements is critical in human health. This study aimed to determine possible changes in levels of bio-elements in children with ARF before and after treatment. Levels of trace and major elements in children with ARF were investigated. The study included 33 children with ARF (17 boys and 16 girls) and 20 healthy control children (11 boys and 9 girls). The ages ranged from 5 to 16 years (mean 11.4 ± 3.82 years) in the study group and from 6 to 15 years (mean, 10.7 ± 3.22 years) in the control group. Trace and major element concentrations (total of 14 elements) in the serum were measured by inductively coupled plasma-optical emission spectroscopy. Before treatment, the levels of the major elements potassium (K) and magnesium (Mg) in children with ARF were higher than in the control group, whereas the calcium (Ca) level was lower. Before treatment, the levels of trace elements iron (Fe), selenium (Se), zinc (Zn), aluminum (Al), and barium (Ba) were lower, whereas the copper (Cu), beryllium (Be), cadmium (Cd), chromium (Cr), gallium (Ga), and strontium (Sr) levels were higher in the serum of the patients with ARF than in the control patients. The major findings show that the homeostasis of some trace and major elements were altered in the children with ARF and that these alterations may be a contributing factor in the pathogenesis of this disease.
急性风湿热（ARF）是一种自身免疫性多系统疾病。生物体需要不同数量的生物元素来维持其生理功能。监测生物元素的状态对人类健康至关重要。本研究旨在确定ARF患儿治疗前后生物元素水平的可能变化。对ARF患儿的微量元素和常量元素水平进行了调查。该研究纳入了33例ARF患儿（17例男孩和16例女孩）和20例健康对照儿童（11例男孩和9例女孩）。研究组年龄范围为5至16岁（平均11.4±3.82岁），对照组年龄范围为6至15岁（平均10.7±3.22岁）。采用电感耦合等离子体发射光谱法测定血清中微量元素和常量元素浓度（共14种元素）。治疗前，ARF患儿的常量元素钾（K）和镁（Mg）水平高于对照组，而钙（Ca）水平较低。治疗前，ARF患儿血清中的微量元素铁（Fe）、硒（Se）、锌（Zn）、铝（Al）和钡（Ba）水平较低，而铜（Cu）、铍（Be）、镉（Cd）、铬（Cr）、镓（Ga）和锶（Sr）水平高于对照患儿。主要研究结果表明，ARF患儿体内一些微量元素和常量元素的稳态发生了改变，这些改变可能是该疾病发病机制中的一个促成因素。
